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FLASH GENE
Symbol ATP6V0D1 contributors: npt/ - updated : 20-09-2004
HGNC name ATPase, H+ transporting, lysosomal 38kDa, V0 subunit d1
HGNC id 13724
Location 16q22.1      Physical location : 67.471.916 - 67.515.089
Synonym name
  • ATPase, H+ transporting, lysosomal 38kDa, V0 subunit d isoform 1
  • V-ATPase AC39 subunit
  • V-ATPase 40 KDa accessory protein
  • ATPase, H+ transporting, lysosomal (vacuolar proton pump), member D
  • Synonym symbol(s) P39, VATX, VMA6, ATP6D, ATP6DV, VPATPD
    EC.number 3.6.3.14
    DNA
    TYPE functioning gene
    SPECIAL FEATURE opposite orientation
    text in opposite orientation, with the 3'end of HSD11B2 and ATP6V0D1 only 0.5 kb apart
    STRUCTURE 43.17 kb     8 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    text structure an alternating purine/pyrimidine tract is located in the 3'untranslated region
    MAPPING cloned Y linked N status provisional
    regionally located located immediately adjacent to HSD11B2
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    8 - 1688 - 351 - -
    EXPRESSION
    Type ubiquitous
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Urinarykidney    
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period pregnancy
    Text placenta
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • the N terminus is blocked
  • HOMOLOGY
    interspecies homolog to C.elegans Y38f2al.e
    ortholog to murine physophilin
    Homologene
    FAMILY
  • V-ATPase V0D/AC39 subunit family
  • CATEGORY enzyme , transport channel
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,lysosome
    basic FUNCTION
  • regulating ATP binding and hydrolysis by the A and B subunits
  • in the epididymis and vas deferens, the vacuolar H(+)ATPase (V-ATPase), located in the apical pole of narrow and clear cells, is required to establish an acidic luminal pH and also participates in the acidification of intracellular organelles (Pietrement 2006)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS electron transport
    text proton transport
    PATHWAY
    metabolism energetic
    signaling
    a component
  • component of vacuolar ATPase (V-ATPase) proton pump
  • complex with ATP6C, ATP6E binding to the hexamer ATP6A/ATP6B
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS