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FLASH GENE
Symbol ATP6V0D1 contributors: npt/ - updated : 20-09-2004
HGNC name ATPase, H+ transporting, lysosomal 38kDa, V0 subunit d1
HGNC id 13724
Location 16q22.1      Physical location : 67.471.916 - 67.515.089
Synonym name
  • ATPase, H+ transporting, lysosomal 38kDa, V0 subunit d isoform 1
  • V-ATPase AC39 subunit
  • V-ATPase 40 KDa accessory protein
  • ATPase, H+ transporting, lysosomal (vacuolar proton pump), member D
  • Synonym symbol(s) P39, VATX, VMA6, ATP6D, ATP6DV, VPATPD
    EC.number 3.6.3.14
    DNA
    TYPE functioning gene
    SPECIAL FEATURE opposite orientation
    text in opposite orientation, with the 3'end of HSD11B2 and ATP6V0D1 only 0.5 kb apart
    STRUCTURE 43.17 kb     8 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    text structure an alternating purine/pyrimidine tract is located in the 3'untranslated region
    MAPPING cloned Y linked N status provisional
    Physical map
    FLJ21736 16q22.1 esterase 31 FLJ37464 16q22.1 hypothetical protein FLJ37464 CBFB 16q22.1 core-binding factor, beta subunit Lin10 16q22.1 lin-10 protein homolog MGC4655 16q22.1 hypothetical protein MGC4655 TRADD 16q22 TNFRSF1A-associated via death domain FBXL8 16q23.1 F-box and leucine-rich repeat protein 8 HSF4 16q21 heat shock transcription factor 4 NOL3 16qp21-q23 nucleolar protein 3 (apoptosis repressor with CARD domain) LOC283849 16q22.1 hypothetical protein LOC283849 E2F4 16q22.1 E2F transcription factor 4, p107/p130-binding ELMO3 16q23.1 engulfment and cell motility 3 (ced-12 homolog, C. elegans) FBXL9 16q23-q31 F-box and leucine-rich repeat protein 9 HSPC171 16q22.1 HSPC171 protein FHOD1 16q22 formin homology 2 domain containing 1 SLC9A5 16q22.1 solute carrier family 9 (sodium/hydrogen exchanger), isoform 5 DKFZP434I216 16q22.1 DKFZP434I216 protein FLJ40162 16q22.1 FLJ40162 protein FLJ11004 16q22.1 hypothetical protein FLJ11004 CGI-38 16q22.1 brain specific protein ZDHHC1 16q23.1 zinc finger, DHHC domain containing 1 HSD11B2 16q22 hydroxysteroid (11-beta) dehydrogenase 2 ATP6V0D1 16q22 ATPase, H+ transporting, lysosomal 38kDa, V0 subunit d isoform 1 AGRP 16q22.1 agouti related protein homolog (mouse) FLJ13725 16q22.1 hypothetical protein FLJ13725 CTCF 16q22.1 CCCTC-binding factor (zinc finger protein) LOC146206 16q22.1 hypothetical protein LOC146206 24432 16q22.1 hypothetical protein 24432 PARD6A 16q22.1 par-6 partitioning defective 6 homolog alpha (C.elegans) DKFZP434A1319 16q22.1 hypothetical protein DKFZp434A1319 LOC388284 16 hypothetical gene supported by BC032064; BC041612 MGC11335 16q22.1 hypothetical protein MGC11335 TSNAXIP1 16q22.2 translin-associated factor X interacting protein 1 FLJ13111 16q22.1 hypothetical protein FLJ13111
    regionally located located immediately adjacent to HSD11B2
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    8 - 1688 - 351 - -
    EXPRESSION
    Type ubiquitous
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Urinarykidney    
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period pregnancy
    Text placenta
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • the N terminus is blocked
  • HOMOLOGY
    interspecies homolog to C.elegans Y38f2al.e
    ortholog to murine physophilin
    Homologene
    FAMILY
  • V-ATPase V0D/AC39 subunit family
  • CATEGORY enzyme , transport channel
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,lysosome
    basic FUNCTION
  • regulating ATP binding and hydrolysis by the A and B subunits
  • in the epididymis and vas deferens, the vacuolar H(+)ATPase (V-ATPase), located in the apical pole of narrow and clear cells, is required to establish an acidic luminal pH and also participates in the acidification of intracellular organelles (Pietrement 2006)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS electron transport
    text proton transport
    PATHWAY
    metabolism energetic
    signaling
    a component
  • component of vacuolar ATPase (V-ATPase) proton pump
  • complex with ATP6C, ATP6E binding to the hexamer ATP6A/ATP6B
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS