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FLASH GENE
Symbol ATP6V0C contributors: - updated : 18-05-2005
HGNC name ATPase, H+ transporting, lysosomal 16kDa, V0 subunit c
HGNC id 855
Location 16p13.3      Physical location : 2.563.952 - 2.570.218
Synonym symbol(s) ATPL, VATL, VMA3, ATP6C, ATP6L
EC.number 3.6.3.14
DNA
TYPE functioning gene
STRUCTURE 1.00 kb     2 Exon(s)
10 Kb 5' upstream gene genomic sequence study
regulatory sequence Promoter
cytosine-phosphate-guanine/HTF
text structure
  • both GC-boxes and E-boxes were identified
  • basal promoter highly complex, with cooperative binding of several transcription factors, including Sp family members
  • MAPPING cloned Y linked N status provisional
    Physical map
    LOC388203 16 LOC388203 LOC283871 16p13.3 hypothetical protein LOC283871 E4F1 16p13.3 E4F transcription factor 1 DNASE1L2 16p13.3 deoxyribonuclease I-like 2 DCI 16p13.3 dodecenoyl-Coenzyme A delta isomerase (3,2 trans-enoyl-Coenzyme A isomerase) RNPS1 16p13.3 RNA binding protein S1, serine-rich domain LOC388204 16 LOC388204 ABCA3 16p13.3 ATP-binding cassette, sub-family A (ABC1), member 3 LOC390669 16 similar to ATP-binding cassette transporter ABCA3 CCNF 16p13.3 cyclin F FLJ13909 16p13.3 hypothetical protein FLJ13909 NTN2L 16p13.3 netrin 2-like (chicken) LOC146446 16p13.3 hypothetical LOC146446 KIAA1171 16p13.3 KIAA1171 protein ATP6V0C 16p13.3 ATPase, H+ transporting, lysosomal 16kDa, V0 subunit c CGI-14 16p13.3 CGI-14 protein PDPK1 16p13.3 3-phosphoinositide dependent protein kinase-1 FLJ39075 16p13.3 hypothetical protein FLJ39075 KCTD5 16p13.3 potassium channel tetramerisation domain containing 5 MPN 16p13.3 pancreasin
    RNA
    TRANSCRIPTS type messenger
    EXPRESSION
    Type widely
    constitutive of
       expressed in (based on citations)
    organ(s)
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Connectivebone   
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Skeletonosteoclast
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • four hydrophobic membrane-spanning alpha helices
  • HOMOLOGY
    Homologene
    FAMILY V-ATPase family
    CATEGORY enzyme , transport carrier
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,lysosome
    basic FUNCTION
  • ATPase H+ transporting, vacuolar proton pump
  • coupling ATP hydrolysis to proton pumping across membranes
  • CELLULAR PROCESS cell organization/biogenesis
    PHYSIOLOGICAL PROCESS electron transport
    text polarization of osteoclats
    PATHWAY
    metabolism energetic
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS