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FLASH GENE
Symbol ATP5O contributors: - updated : 18-10-2006
HGNC name ATP synthase, H+ transporting, mitochondrial F1 complex, O subunit (oligomycin sensitivity conferring protein)
HGNC id 850
Location 21q22.1-q22.2      Physical location : 35.275.757 - 35.288.158
Synonym name
  • oligomycin sensitivity conferring protein
  • Synonym symbol(s) ATPO, OSCP
    EC.number 3.6.3.14
    DNA
    TYPE functioning gene
    STRUCTURE 12.00 kb     7 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked   status confirmed
    Physical map
    C21orf66 21q22.11 chromosome 21 open reading frame 66 C21orf62 21q22.1 chromosome 21 open reading frame 62 OLIG2 21q22.11 oligodendrocyte lineage transcription factor 2 C21orf54 21q22.11 chromosome 21 open reading frame 54 IFNAR2 21q22.1 interferon (alpha, beta and omega) receptor 2 IL10RB 21q22.1-q22.2 interleukin 10 receptor, beta IFNAR1 21q22.1 interferon (alpha, beta and omega) receptor 1 IFNGR2 21q22.1 interferon gamma receptor 2 (interferon gamma transducer 1) C21orf4 21q22.1-q22.2 chromosome 21 open reading frame 4 RPS5L 21q22.11 ribosomal protein S5-like C21orf55 21q22.11 chromosome 21 open reading frame 55 GART 21q22.1 phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase SON 21q22.1-q22.2 SON DNA binding protein DONSON 21q22.1 downstream neighbor of SON CRYZL1 21q22.1 crystallin, zeta (quinone reductase)-like 1 ITSN1 21q22.1-q22.2 intersectin 1 (SH3 domain protein) ATP5O 21q22.1-q22.2 ATP synthase, H+ transporting, mitochondrial F1 complex, O subunit (oligomycin sensitivity conferring protein) LOC388819 21 similar to GNGT1 protein MRPS6 21q21.3-q22.1 mitochondrial ribosomal protein S6 SLC5A3 21q22.1 solute carrier family 5 (inositol transporters), member 3 C21orf82 21q22.1 chromosome 21 open reading frame 82 KCNE2 21q22.12 potassium voltage-gated channel, Isk-related family, member 2 C21orf51 21q22.12 chromosome 21 open reading frame 51 LOC388820 21 hypothetical gene supported by BC049386 KCNE1 21q22.2 potassium voltage-gated channel, Isk-related family, member 1 DSCR1 21q22.1-q22.2 Down syndrome critical region gene 1 CLIC6 21q22.12 chloride intracellular channel 6 RUNX1 21q22.1-q22.3 runt-related transcription factor 1 (acute myeloid leukemia 1; AML1 oncogene)
    RNA
    TRANSCRIPTS type messenger
    EXPRESSION
    Type ubiquitous
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart   highly
    Endocrineadrenal gland   moderately
     parathyroid   highly
    Lymphoid/Immunetonsils   highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Muscularstriatumskeletal  
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period fetal
    Text umbilical cord
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a 23 aa transit peptide (2.4 kda)
  • isoforms Precursor a 189 aa mature peptide (20.9 kda)
    HOMOLOGY
    interspecies homolog to rattus Atp5o (81.7pc)
    homolog to murine Atp5o (82.2pc)
    Homologene
    FAMILY
  • ATPase delta chain family
  • CATEGORY enzyme , transport
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria,inner
    intracellular,cytoplasm,organelle,mitochondria,matrix
    basic FUNCTION
  • acting as a catalytic unit of the ATP synthesis
  • being part of the stalk that links CF(0) to CF(1)
  • transmiting conformational changes from CF(0) into CF(1)
  • implicated in proton conduction
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    text
  • protein
  • proton
  • PATHWAY
    metabolism energetic
    signaling
  • oxydative phosphorylation
  • a component
  • constituent of mitochondrial matrix F0 segment
  • component of complex V of oxidative phosphorylation (OXPHOS)
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    inhibited by immunomodulatory benzodiazepine Bz-423 (in vitro)
    ASSOCIATED DISORDERS
    corresponding disease(s)
    related resource MITOP database
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target for lupus
    ANIMAL & CELL MODELS