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FLASH GENE
Symbol ATP5MC3 contributors: mct - updated : 21-05-2019
HGNC name ATP synthase membrane subunit c locus 3
HGNC id 843
Location 2q31.1      Physical location : -
Synonym name
  • ATP synthase, H+ transporting, mitochondrial F0 complex, subunit C3 (subunit 9)
  • Synonym symbol(s) AT93, P3, ATP5G3, MGC125738
    EC.number 3.6.3.14, 3.6.1.14
    DNA
    TYPE functioning gene
    STRUCTURE 5.50 kb     7 Exon(s)
    MAPPING cloned Y linked N status confirmed
    RNA
    TRANSCRIPTS type messenger
    text Alternatively spliced transcript variants encoding the same protein
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    5 - 2651 - 142 - 2017 28289229
  • 5 exons
  • a 75 mature peptide of 7.6 kda
  • differing in the 5' UTR compared to variant 3
  • 4 - 2741 - 142 - 2017 28289229
  • 4 exons
  • a 75 mature peptide of 7.6 kda
  • 4 - 3305 - 105 - 2017 28289229
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart   highly
    Digestiveesophagus   moderately
     intestinesmall intestine  moderately
     intestinelarge intestinecolon moderately
     liver   moderately
     pancreas exocrine   highly
     salivary gland   moderately
     stomach   moderately
    Endocrineneuroendocrinepituitary  moderately
     parathyroid   predominantly
    Hearing/Equilibriumear   highly
    Reproductivefemale systemovary  moderately
     female systembreastmammary gland moderately
     female systemuterus  moderately
    Respiratorylung   moderately
    Skin/Tegumentskin   highly
    Urinarybladder   moderately
     kidney   moderately
    Visualeye   moderately
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / hematopoieticbone marrow  highly
    Connectiveadipose  moderately
    Connectivebone  highly
    Muscular   moderately
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period fetal
    Text umbilical cord
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    HOMOLOGY
    interspecies ortholog to rattus Atp5g3 (100pc)
    ortholog to murine Atp5g3 (95.7pc)
    Homologene
    FAMILY ATPase c chain family
    CATEGORY enzyme , transport
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria,outer
    intracellular,cytoplasm,organelle,membrane
    basic FUNCTION
  • involved in ATP synthesis coupled proton transport
  • ATP5MC1, ATP5MC2, ATP5MC3 are nonredundant, because they differ functionally by their targeting peptides, which, in addition to mediating mitochondrial protein import, play a yet undiscovered role in respiratory chain maintenance
  • catalyzes ATP synthesis during oxidative phosphorylation in mitochondria
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS mitochondrial transport
    text
  • ion transport
  • proton transport
  • PATHWAY
    metabolism
    signaling
    a component
  • constituent of mitochondrial matrix F0 segment
  • component of complex V of oxidative phosphorylation (OXPHOS)
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
  • lipid
  • REGULATION
    activated by thyroid hormones
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS