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Symbol ATP5MC1 contributors: mct - updated : 21-05-2019
HGNC name ATP synthase membrane subunit c locus 1
HGNC id 841
Location 17q21.32      Physical location : -
Synonym name
  • ATP synthase, H+ transporting, mitochondrial F0 complex, subunit C1 (subunit 9)
  • mitochondrial ATP synthase, subunit 9, isoform 1
  • ATP synthase proteolipid P1
  • mitochondrial ATP synthase, subunit C, isoform 1
    • Synonym symbol(s) ATP5G, ATP5A, ATP5G1
    EC.number 3.6.1.34
    DNA
    TYPE functioning gene
    STRUCTURE 3.09 kb     5 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    5 - 663 - 136 - 2017 28289229
    5 - 593 - 136 - 2017 28289229
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveliver    
    Nervousbrain    
    Respiratorylung    
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    HOMOLOGY
    interspecies homolog to murine Atp5g1
    Homologene
    FAMILY
  • ATPase C chain family
    • CATEGORY enzyme , transport
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria,inner
    intracellular,cytoplasm,organelle,membrane
    basic FUNCTION
  • ATP synthesis, catalytic unit
  • ATP5MC1, ATP5MC2, ATP5MC3 are nonredundant, because they differ functionally by their targeting peptides, which, in addition to mediating mitochondrial protein import, play a yet undiscovered role in respiratory chain maintenance
  • key component of Complex V of the oxidative phosphorylation chain, that is likely present in the axons of primary sympathetic neurons
  • role for ZC3H14 in ensuring proper nuclear processing and retention of ATP5G1 pre-mRNA
  • ATP5MC1, ATP5MC2, ATP5MC3, that are involved directly in transmembrane proton translocation are not involved in forming the permeability transition pore (PTP), in the inner mitochondrial membrane
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism energetic
    signaling
    oxydative phosphorylation
    a component
  • constituent of mitochondrial matrix F0 segment
  • component of complex V of oxidative phosphorylation (OXPHOS)
    • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • DCCD (dicyclohexylcarbodiimidine) reactive
  • ATP5G1 and DLG4 are shared RNA targets of ZC3H14 and the THO complex
    • cell & other
    REGULATION
    Other
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS