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FLASH GENE
Symbol ATP5B contributors: mct - updated : 04-07-2011
HGNC name ATP synthase, H+ transporting, mitochondrial F1 complex, beta polypeptide
HGNC id 830
Location 12q13.3      Physical location : 57.031.960 - 57.039.852
Synonym name
  • mitochondrial ATP synthetase, beta subunit
  • beta-F1-ATPase
    • Synonym symbol(s) ATPSB, ATPMB, MGC5231
    EC.number 3.6.3.14
    DNA
    TYPE functioning gene
    STRUCTURE 7.89 kb     10 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status confirmed
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    10 - 1857 51.8 529 - 2010 20663914
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Visualeyeanterior segmentcornea  
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / Hematopoieticbone marrow   
    Muscularstriatumcardiac  
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Blood/Hematopoieticprogenitor cell
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • nucleotide binding sites
    • isoforms Precursor
    HOMOLOGY
    Homologene
    FAMILY
  • ATPase alpha/beta chains family
    • CATEGORY enzyme , transport
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria,inner
    intracellular,cytoplasm,organelle,mitochondria,matrix
    basic FUNCTION
  • ATP synthesis, catalytic unit
  • its ectopic localization may participate in the energy balance of cells in response to the change in intracellular cholesterol levels
  • may have an important role in the glucolipotoxicity of islet cells,suggesting that ATP synthase beta-subunit might be a target of lipotoxicity in beta-cells
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    text protein
    PATHWAY
    metabolism energetic
    signaling
    oxydative phosphorylation
    a component
  • constituent of mitochondrial matrix F1 segment
  • component of complex V of oxidative phosphorylation (OXPHOS)
    • INTERACTION
    DNA
    RNA
    small molecule nucleotide,
  • ADP
  • ATP
  • Pi binding
  • direct interaction of the endogenous G3BP1 with ATP5B (interaction of G3BP1 with the 3prime-UTR of beta-F1 mRNA in cytoplasmic RNA-granules)
    • protein
  • enterostatin receptor
  • functions as a receptor for ATP5J and may have a previously unsuspected role in the genesis of hypertension by modulating the concentration of intracellular hydrogen
  • interacting with CACNA2D1 (may interact with other cellular components in developing myotubes, such as the ATP5B in its atypical localization in the plasma membrane)
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    related resource MITOP database
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • expression level of ATP5B provides a marker of the prognosis of cancer patients, as well as of the tumour response to chemotherapy
    • Therapy target
    ANIMAL & CELL MODELS