basic FUNCTION
| playing a role in lactation that may go beyond the supply of Ca2+ to the Golgi for secretion into milk, and relate to the control of Ca2+ and Mn2+ ions in the Golgi for the regulation of Golgi-localized Ca2+ and Mn2+ sensitive enzymes, which are critical for post-translational modification of milk proteins and lactose production |
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has the ability to transport Ca(2+), a Mn(2+)-transporting activity, a Ca(2+)- and Mn(2+)-dependent phosphoprotein intermediate formation |
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important physiological role in the brain |
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up-regulation of SPCA2 may function to supply the secretory pathway with Ca2+ ions for packaging into casein micelles for calcium secretion into milk |
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CMIP and ATP2C2 act to modulate phonological short-term memory primarily in the context of language impairment |
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may play a role in regulating basal Ca2+, and its upregulation results in constitutive increase of basal Ca2+ and cell proliferation associated with oncogenesis |
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promotion of tumorigenic pathways by ATP2C2 in breast cancer cells, mediated by interaction with ORAI1 |