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FLASH GENE
Symbol ATP2C2 contributors: mct/npt/pgu - updated : 25-03-2011
HGNC name ATPase, Ca++ transporting, type 2C, member 2
HGNC id 29103
Location 16q24.2      Physical location : 84.402.132 - 84.497.792
Synonym name
  • cDNA sequence, expressed in brain, 63kDa, related to S cerevisiae calcium transporting ATPase 1
  • calcium-transporting ATPase type 2C member 2
  • ATPase 2C2
  • calcium-transporting ATPase 2C2
  • secretory pathway calcium ATPase 2
  • Synonym symbol(s) KIAA0703, SPCA2, DKFZp686H22230
    EC.number 3.6.3.8
    DNA
    TYPE functioning gene
    STRUCTURE 95.66 kb     27 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    27 - 3403 - 946 - 2006 16332677
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestivemouth   highly
    Nervousbrain   predominantly Homo sapiens
    Reproductivemale systemtestis  highly Homo sapiens
    Respiratorylung   highly
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Nervousneuron Homo sapiens
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • N terminus of ATP2C2 binds ORAI1, resulting in a conformational change and exposure of the C terminus, which can interact with ORAI1 either directly or together with other proteins to activate Ca2+ influx
  • HOMOLOGY
    interspecies homolog to yeast S.cerevisiae calcium transporting ATPase 1
    intraspecies homolog to ATP2C1 (64 p100)
    Homologene
    FAMILY
  • cation transport ATPase (P-type) family
  • type IIA subfamily
  • CATEGORY unknown/unspecified
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,Golgi
    basic FUNCTION
  • playing a role in lactation that may go beyond the supply of Ca2+ to the Golgi for secretion into milk, and relate to the control of Ca2+ and Mn2+ ions in the Golgi for the regulation of Golgi-localized Ca2+ and Mn2+ sensitive enzymes, which are critical for post-translational modification of milk proteins and lactose production
  • has the ability to transport Ca(2+), a Mn(2+)-transporting activity, a Ca(2+)- and Mn(2+)-dependent phosphoprotein intermediate formation
  • important physiological role in the brain
  • up-regulation of SPCA2 may function to supply the secretory pathway with Ca2+ ions for packaging into casein micelles for calcium secretion into milk
  • CMIP and ATP2C2 act to modulate phonological short-term memory primarily in the context of language impairment
  • may play a role in regulating basal Ca2+, and its upregulation results in constitutive increase of basal Ca2+ and cell proliferation associated with oncogenesis
  • promotion of tumorigenic pathways by ATP2C2 in breast cancer cells, mediated by interaction with ORAI1
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
  • signaling pathway in which the ORAI1-ATP2C2 complex elicits constitutive store-independent Ca2+ signaling that promotes tumorigenesis
  • a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacts with ORAI1 to mediate Ca2+ entry
  • cell & other
    REGULATION
    Other regulated by BHLHA15 (role in regulating the ATP2C2 gene in pancreatic acinar cell)
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --over  
    35-fold during lactation with expression localized to luminal secretory cells
    tumoral     --over  
    in breast cancer
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancerreproductivebreast
    both ATP2C2 and ORAI1 emerge as druggable targets of therapeutic potential in the treatment of some breast cancer subtypes
    ANIMAL & CELL MODELS