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FLASH GENE

Symbol

ATP2B4

contributors: mct - updated : 26-03-2011

HGNC name	ATPase, Ca++ transporting, plasma membrane 4
HGNC id	817

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	1q32      Physical location : 203.595.927 - 203.713.207
Synonym name	matrix-remodelling associated 1
	plasma membrane calcium pump isoform 4
Synonym symbol(s)	PMCA4, ATP2B2, MXRA1
EC.number	3.6.1.38

DNA

TYPE	like-sequence
STRUCTURE	117.28 kb     22 Exon(s)

Genomic sequence alignment details
10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

Y

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_001001396 22 - 8911 - 1170 - 2005 16216224 NM_001684 21 - 8733 - 1205 - 2005 16216224 an organizer of macromolecular protein complexes, which could recruit diverse proteins through interaction with different domains functional association with RASSF1 indicates a role for PMCA4b in the modulation of Ras-mediated signaling

EXPRESSION

Type	ubiquitous

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive intestine small intestine     highly Reproductive female system placenta     highly Respiratory respiratory tract larynx     highly

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Muscular striatum skeletal

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	a C-terminal domain referred to as a regulatory domain
	10 transmembrane domains
	two large intracellular loops
	and N- and C-terminal cytoplasmic tails

HOMOLOGY

interspecies	ortholog to murine Atp2b4
	ortholog to rattus atp2b4

Homologene

FAMILY

P-type primary ion transport ATPases family

CATEGORY

transport carrier

SUBCELLULAR LOCALIZATION

plasma membrane

basic FUNCTION	mediating the extrusion of CA2+ from the cell
	magnesium-dependent enzyme catalyzing the hydrolysis of ATP coupled with the transport of calcium out of the cell
	extrude Ca2+ from cells, maintaining the resting level of intracellular Ca2+ and controlling the Ca2+ transients induced by agonists
	importance of oligomerization for the regulation of ATP2B4 activity and intracellular calcium concentration

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein

Ca(2+) homeostasis in sperm is maintained by the relative ratios of CASK-ATP2B4 and CASK-F11R interactions

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS