Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol ATP2B4 contributors: mct - updated : 26-03-2011
HGNC name ATPase, Ca++ transporting, plasma membrane 4
HGNC id 817
Location 1q32      Physical location : 203.595.927 - 203.713.207
Synonym name
  • matrix-remodelling associated 1
  • plasma membrane calcium pump isoform 4
  • Synonym symbol(s) PMCA4, ATP2B2, MXRA1
    EC.number 3.6.1.38
    DNA
    TYPE like-sequence
    STRUCTURE 117.28 kb     22 Exon(s)
    Genomic sequence alignment details
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked Y status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    22 - 8911 - 1170 - 2005 16216224
    21 - 8733 - 1205 - 2005 16216224
  • an organizer of macromolecular protein complexes, which could recruit diverse proteins through interaction with different domains
  • functional association with RASSF1 indicates a role for PMCA4b in the modulation of Ras-mediated signaling
  • EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveintestinesmall intestine  highly
    Reproductivefemale systemplacenta  highly
    Respiratoryrespiratory tractlarynx  highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Muscularstriatumskeletal  
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a C-terminal domain referred to as a regulatory domain
  • 10 transmembrane domains
  • two large intracellular loops
  • and N- and C-terminal cytoplasmic tails
  • HOMOLOGY
    interspecies ortholog to murine Atp2b4
    ortholog to rattus atp2b4
    Homologene
    FAMILY P-type primary ion transport ATPases family
    CATEGORY transport carrier
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • mediating the extrusion of CA2+ from the cell
  • magnesium-dependent enzyme catalyzing the hydrolysis of ATP coupled with the transport of calcium out of the cell
  • extrude Ca2+ from cells, maintaining the resting level of intracellular Ca2+ and controlling the Ca2+ transients induced by agonists
  • importance of oligomerization for the regulation of ATP2B4 activity and intracellular calcium concentration
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • Ca(2+) homeostasis in sperm is maintained by the relative ratios of CASK-ATP2B4 and CASK-F11R interactions
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS