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FLASH GENE
Symbol ATP2A3 contributors: mct/pgu - updated : 30-11-2011
HGNC name ATPase, Ca++ transporting, ubiquitous
HGNC id 813
Location 17p13.2      Physical location : 3.827.168 - 3.867.736
Synonym name
  • calcium-translocating P-type ATPase
  • sarco/endoplasmic reticulum Ca2+ -ATPase
  • sarcoplasmic/endoplasmic reticulum calcium ATPase 3
  • calcium pump 3
  • Synonym symbol(s) SERCA3
    EC.number 3.6.1.38, 3.6.3.8
    DNA
    TYPE functioning gene
    STRUCTURE 40.57 kb     23 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    text structure no TATA box,many binding sites
    MAPPING cloned Y linked N status confirmed
    Physical map
    OR1P1P 17p13.3 olfactory receptor, family 1, subfamily P, member 1 pseudogene OR1A2 17p13.3 olfactory receptor, family 1, subfamily A, member 2 OR1A1 17p13.3 olfactory receptor, family 1, subfamily A, member 1 OR1D3P 17p13.3 olfactory receptor, family 1, subfamily D, member 3 pseudogene OR3A2 17p13.3 olfactory receptor, family 3, subfamily A, member 2 OR3A1 17p13.3 olfactory receptor, family 3, subfamily A, member 1 LOC390756 17 similar to Olfactory receptor 3A4 (Olfactory receptor 17-24) (OR17-24) LOC390757 17 similar to olfactory receptor MOR157-1 OR1E1 17p13.3 olfactory receptor, family 1, subfamily E, member 1 OR3A3 17p13.3 olfactory receptor, family 3, subfamily A, member 3 OR1E2 17p13.3 olfactory receptor, family 1, subfamily E, member 2 NYD-SP20 17p13.3 testes development-related NYD-SP20 ASPA 17p13.3 aspartoacylase (aminoacylase 2, Canavan disease) TRPV3 17p13.3 transient receptor potential cation channel, subfamily V, member 3 TRPV1 17p13.3 transient receptor potential cation channel, subfamily V, member 1 CARKL 17p13 carbohydrate kinase-like CTNS 17p13.3 cystinosis, nephropathic TIP-1 17p13 Tax interaction protein 1 MGC2963 17p13.3 hypothetical protein MGC2963 P2RX5 17p13 purinergic receptor P2X, ligand-gated ion channel, 5 ITGAE 17p13 integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide) GSG2 17p13 integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide) HSA277841 17p13.3 ELG protein CAMKK1 17p13.3 calcium/calmodulin-dependent protein kinase kinase 1, alpha P2RX1 17p13.3 purinergic receptor P2X, ligand-gated ion channel, 1 ATP2A3 17p13.3 ATPase, Ca++ transporting, ubiquitous KIAA0399 17p13.3 KIAA0399 protein MGC32124 17p13.3 hypothetical protein MGC32124 ANKFY1 17p13.3 ankyrin repeat and FYVE domain containing 1 UBE2G1 1q42 ubiquitin-conjugating enzyme E2G 1 (UBC7 homolog, C. elegans) MGC29671 17p13.3 hypothetical protein MGC29671 LOC124976 17p13.3 hypothetical protein LOC124976 MYBBP1A 17p13.3 MYB binding protein (P160) 1a FLJ90165 17p13.3 hypothetical protein FLJ90165 LOC124974 17p13.3 thioredoxin 1 pseudogene 4 FLJ42461 17p13.3 FLJ42461 protein ALOX15 17p13.1 arachidonate 15-lipoxygenase
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    21 splicing 4698 109.2 999 platelets, major isoform, and in the heart 2004 15028735
  • also called SERCA3a or variant 1/isoform a
  • lacking exon 11
  • 22 splicing 4786 - 1043 platelets 2006 16725111
  • also called SERCA3b or variant 2/isoform b
  • exon 21 included
  • ER location
  • overexpression of SERCA3b affected cell adhesion capacity associated with a major disorganization of F-actin and a decrease in focal adhesion
  • 22 splicing 4799 - 1029 patelets 2004 15028735
  • also called SERCA3c or variant 3/isoform c
  • exon 21 partially included
  • 23 - 4844 - 1044 in the heart 2004 15028735
    also called SERCA3d or variant 4/isoform d
    23 - 4857 - 1052 - 2004 15028735
    also called variant 5/isoform e
    21 - 4695 - 998 in the heart 2006 16725111
  • also called SERCA3f or variant 6/isoform f
  • exclude the antepenultimate exon 21
  • diverged in the first amino acids after the first splice site but presented the same last 21 amino acids as SERCAb
  • ER location
  • SERCA3f overexpression resulted in an increase in endoplasmic reticulum stress markers (including processing of XBP1 mRNA and expression of GRP78)
  • 23 - 4205 - 1029 - 2004 15028735
    also called variant 7/isoform c
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularvesselcapillary   
    Digestiveintestine    
    Endocrinepancreas   highly
    Lymphoid/Immunelymph node   highly
    Skin/Tegumentskin appendagesskin glandsweat glandeccrine sweat gland 
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / hematopoieticbone marrow   
    Muscularstriatumcardiac  
    Muscularstriatumskeletal  
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Blood/Hematopoieticplatelet
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period fetal, pregnancy
    Text various tissues
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • ten transmembrane coiled coil helices
  • four of which containing Ca2+ binding sites
  • a cytoplasmic beta strand between TM2/3,l
  • a phosphorylation and ATP binding globular domains (the latter linked to stalk sector 5) between TM4/5
  • HOMOLOGY
    Homologene
    FAMILY
  • P-type cation pump family
  • CATEGORY enzyme , transport
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria,interspace
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    intracellular,nucleus
    intracellular,nuclear envelope
    text sarco/endoplamic membrane nuclear envelop isoform ATP2A3
    basic FUNCTION
  • mediating the extrusion of CA2+ from internal stores in the endoplasmic reticulum
  • sarco/endoplasmic reticulum Ca2+ pump (role in cellular calcium signaling)
  • with ATP2A2, modulate thrombin-stimulated SOCE (store-operated Ca(2+)entry) probably by direct interaction with the TRPC1 channel inplatelets
  • low Ca2+-affinity ATP2A3, and the high Ca2+-affinity ATP2A2 enzymes are simultaneously expressed in B cells
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS active transport
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • STIM2 associates with ORAI1 and ATP2A3 upon discharge of the acidic Ca2+ stores in human platelets
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    functional remodelling of ER calcium homeostasis by down-regulation of SERCA3 expression constitutes a previously unknown mechanism involved in EBV-induced B cell immortalisation (
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS