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FLASH GENE
Symbol ATP1A4 contributors: mct - updated : 21-02-2018
HGNC name ATPase, Na+/K+ transporting, alpha 4 polypeptide
HGNC id 14073
Location 1q22      Physical location : 160.121.351 - 160.156.766
Synonym name
  • ATPase, Na+/K+ transporting, alpha polypeptide-like 2
  • Na,K-ATPase subunit alpha-C
  • Synonym symbol(s) ATP1AL2, RP11-536C5.5, ATP1A1
    EC.number 3.6.3.9
    DNA
    TYPE functioning gene
    SPECIAL FEATURE arranged in tandem
    text arranged in tandem with ATP1A2
    STRUCTURE 35.00 kb     22 Exon(s)
    Genomic sequence alignment details
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status confirmed
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    - - 3873 - 1029 - Lingrel
    - - 951 - 165 - Lingrel
    EXPRESSION
    Type restricted
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Reproductivemale systemtestis   
    Urinarybladder    
    cell lineage
    cell lines cDNA transfected 3T3 cells
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    Homologene
    FAMILY cation transport ATPase (p-type) family
    CATEGORY transport carrier
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • involved in osmotic balance and cell volume stability
  • catalyzing the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma
  • involved in specialized functions of various tissues, helping to explain their tissue- and developmental-specific regulation membrane
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS active transport
    text Na+,K+ pump
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule nucleotide,
    ATP
    protein
  • GPNMB promotes glioma growth via ATP1A1, ATP1A2, ATP1A3, ATP1A4
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS