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FLASH GENE
Symbol ATP11C contributors: mct - updated : 17-12-2011
HGNC name ATPase, Class VI, type 11C
HGNC id 13554
Location Xq27.1      Physical location : 138.808.505 - 138.914.447
Synonym name
  • polyadenylated sequence AS6
  • phospholipid-transporting ATPase 11C
  • Synonym symbol(s) ATPIG, ATPIQ, FLJ34233, AS6
    EC.number 3.6.3.1
    DNA
    TYPE functioning gene
    STRUCTURE 105.94 kb     30 Exon(s)
    text structure AS6 sequence is the 3'UTR
    MAPPING cloned Y linked N status provisional
    Map cen - F9 - MCF2 - ATP11C - SOX3 - DXS984 - qter
    Authors Nesbit (04)
    Physical map
    ZIC3 Xq26.2 Zic family member 3 heterotaxy 1 (odd-paired homolog, Drosophila) LOC389892 X similar to Mothers against decapentaplegic homolog interacting protein (Madh-interacting protein) (Smad anchor for receptor activation) (Receptor activation anchor) (hSARA) (Novel serine protease) (NSP) LOC139363 Xq27.1 similar to melanoma antigen, family A, 10; melanoma-associated antigen 10; MAGE-10 antigen LOC392552 X similar to cytokeratin 8 FLJ30672 Xq27.1 hypothetical protein FLJ30672 FGF13 Xq26 fibroblast growth factor 13 SRD5AP1 Xq24-qter steroid-5-alpha-reductase, alpha polypeptide pseudogene 1 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha pseudogene) F9 Xq26.3-q27.1 coagulation factor IX (plasma thromboplastic component, Christmas disease, hemophilia B) MCF2 Xq26.3-q27.1 MCF.2 cell line derived transforming sequence BCYRN1P1  brain cytoplasmic RNA 1, pseudogene 1 ATP11C X ATPase, Class VI, type 11C LOC347487 Xq27.1 hypothetical LOC347487 LOC389893 X LOC389893 LOC389894 X hypothetical gene supported by NM_194247 LOC389895 X similar to PRO0149 protein LOC389896 X LOC389896 LOC266694 Xq27.1 embryonic ectoderm development pseudogene SOX3 Xq27.1 SRY (sex determining region Y)-box 3 CDR1 Xq27.1-q27.2 cerebellar degeneration-related protein 1, 34kDa SPANXB1 Xq27.1 SPANX family, member B1 dJ507I15.1 Xq27.1 ribosomal protein L36a pseudogene LDOC1 Xq27.2 leucine zipper, down-regulated in cancer 1 SPANXC Xq27.1 SPANX family, member C NDUFB3P5  NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 3, 12kDa pseudogene 5 SPANXA1 Xq27.1 sperm protein associated with the nucleus, X chromosome, family member A1 LOC389897 X hypothetical gene supported by BC042039 SPANXE Xq27.1 SPANX family, member E SPANXD Xq27.1 SPANX family, member D MAGEC3 Xq27.2 melanoma antigen, family C, 3 MAGEC1 Xq26 melanoma antigen, family C, 1
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    30 - 6128 129 1132 - 2004 15533723
    29 - 6023 128 1119 - 2004 15533723
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart    
    Digestiveliver    
    Endocrinepancreas    
    Nervousbrain    
    Reproductivemale systemprostate   
    Urinarykidney    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Epithelialsecretoryglandularendocrine 
    Epithelialsecretoryglandularexocrine 
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    haloacid dehalogenase-like hydrolase domain
    HOMOLOGY
    interspecies homolog to Drosophila CG17034
    homolog to C.elegans Y49E10.11
    Homologene
    FAMILY
  • the cation transport ATpases (P-type) family
  • type IV subfamily
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    basic FUNCTION
  • magnesium-dependent enzyme catalyzing the hydrolysis of ATP coupled with the transport of calcium
  • critical for the internalization of phosphatidylserine and differentiation of B lymphocytes
  • essential, cell-autonomous and context-sensitive function for ATP11C, a putative aminophospholipid flippase, in B cell development
  • multifunctional transporter, essential for adult B-cell development, the prevention of intrahepatic cholestasis, and parturition
  • key nonhematopoietic role for ATP11C, specifically in the prevention of intrahepatic cholestasis
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule nucleotide,
    ATP
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene candidate for genetically undiagnosed cases of cholestasis and dystocia in humans
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • mutation of the X-linked mouse gene Atp11c, which encodes a paralogous P4-type ATPase, precludes B-cell development in the adult bone marrow, but also causes hyperbilirubinemia