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FLASH GENE
Symbol ATP10D contributors: mct - updated : 30-06-2021
HGNC name ATPase, Class V, type 10D
HGNC id 13549
Location 4p12      Physical location : 47.487.409 - 47.595.503
Synonym name
  • putative type IV aminophospholipid transporting ATPase
  • P4-ATPase flippase complex alpha subunit ATP10D
  • probable phospholipid-transporting ATPase VD
  • Synonym symbol(s) ATPVD, KIAA1487
    EC.number 3.6.3.1/7.6.2.1
    DNA
    TYPE functioning gene
    STRUCTURE 108.21 kb     23 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    23 - 6668 160.2 1426 - 2013 24125428
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveliver     Homo sapiens
    Nervousbrain     Homo sapiens
    Reproductivemale systemprostate   
     male systemtestis    Homo sapiens
    Respiratorylung    
    Urinarykidney     Homo sapiens
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period pregnancy
    Text placenta
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    Homologene
    FAMILY
  • cation transport atpases family (p-type atpases)
  • subfamily IV
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    intracellular,nucleus,nucleoplasm
    basic FUNCTION
  • involved in the active transport of charged substrates across biological membranes
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility to elevated levels of glucosylceramide (GlcCer) in plasma
    Variant & Polymorphism SNP
  • ATP10D SNPs are associated with elevated levels of glucosylceramide (GlcCer) in plasma from diverse European populations
  • Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • deficiency of Atp10a and Atp10d leads to insulin resistance and obesity in mice