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FLASH GENE
Symbol ATOX1 contributors: mct - updated : 09-02-2011
HGNC name ATX1 antioxidant protein 1 homolog (yeast)
HGNC id 798
Location 5q33.1      Physical location : 151.122.383 - 151.138.210
Synonym name
  • ATX yeast homolog of 1
  • metal transport protein ATX1
  • copper transport protein ATOX1
  • Synonym symbol(s) ATX1, HAH1, MGC138453, MGC138455
    DNA
    TYPE functioning gene
    STRUCTURE 15.83 kb     4 Exon(s)    1 Copie(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status confirmed
    Map cen - ADRB2 - CSF1R - CDX1 - RPS14 - D5S470 - D5S1419 - SPARC - D5S2416 /ATOX1- D5S1638 - D5S2077 - GRIA1 - MFAP3 - qter
    Physical map
    CAMK2A 5q33.2 calcium/calmodulin-dependent protein kinase (CaM kinase) II alpha LOC340075 5q33.1 similar to RIKEN cDNA 9330196J05 TCOF1 5q32-q33.1 Treacher Collins-Franceschetti syndrome 1 CD74 5q31.3 CD74 antigen (invariant polypeptide of major histocompatibility complex, class II antigen-associated) RPS14 5q32 ribosomal protein S14 NDST1 5q31.3-q32 N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1 SYNPO 5q33.1 synaptopodin MYOZ3 5q33.1 myozenin 3 FLJ10290 5q33.1 hypothetical protein FLJ10290 DCTN4 5q31-q32 dynactin 4 (p62) NID67 5q33.1 putative small membrane protein NID67 LRG47 5q33.1 LRG-47-like protein ZNF300 21 zinc finger protein 300 GPX3 5q23 glutathione peroxidase 3 (plasma) TNIP1 5q32-q33.1 TNFAIP3 interacting protein 1 ANXA6 5q32 annexin A6 DKFZP434C171 5q33.1 DKFZP434C171 protein GM2A 5q32 GM2 ganglioside activator protein SLC36A3 5q33.1 solute carrier family 36 (proton/amino acid symporter), member 3 SLC36A2 5q33.1 solute carrier family 36 (proton/amino acid symporter), member 2 LOC391840 5 similar to Thyroid hormone receptor-associated protein complex 240 kDa component (Trap240) (Activator-recruited cofactor 250 kDa component) (ARC250) LOC391841 5 similar to hypothetical protein DKFZp761H0421 SLC36A1 5q33.1 solute carrier family 36 (proton/amino acid symporter), member 1 FAT2 5q31-q32 FAT tumor suppressor homolog 2 (Drosophila) SPARC 5q32 secreted protein, acidic, cysteine-rich (osteonectin) ATOX1 5q32-q33 ATX1 antioxidant protein 1 homolog (yeast) LOC389338 5 LOC389338 G3BP 5q33.3 LOC389338 GLRA1 5q32 glycine receptor, alpha 1 (startle disease/hyperekplexia, stiff man syndrome) GLULL1 5q33 glutamate-ammonia ligase (glutamine synthase)-like 1 NMU2R 5q33.2 neuromedin U receptor 2
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    4 - 498 - 68 - 2000 10982193
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart   highly
    Lymphoid/Immunespleen   highly
     thymus   highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / hematopoieticbone marrow   
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • N-terminal copper-binding domain (heavy metal associated sequence (HMA)
  • a lysine-rich C terminus
  • C-terminal KKTGK motif, conserved lysine-rich region which may represent the nuclear localization signal
  • conjugated MetalloP
    HOMOLOGY
    interspecies homolog to yeast S.cerevisiae
    homolog to murine Atox1
    Homologene
    FAMILY
  • ATX1 family
  • CATEGORY chaperone/stress , transport
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,Golgi
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus
    text translocated to the nucleus in response to copper through its highly conserved C-terminal KKTGK motif
    basic FUNCTION
  • copper chaperone playing a role in copper homeostasis by binding and transporting cytosolic copper to ATPase proteins in the trans-Golgi network for later incorporation to the ceruloplasmin
  • involved in copper homeostasis (perinatal copper homeostasis)
  • copper-dependent transcription factor that mediates copper-induced cell proliferation
  • functions as a novel transcription factor that, when activated by copper, undergoes nuclear translocation, DNA binding, and transactivation, thereby contributing to cell proliferation
  • might have acquired nuclear function in addition to its copper chaperone function for the secretory compartment during the course of evolution
  • may contribute to hyperproliferative conditions such as cancer, angiogenesis, and atherosclerosis
  • copper chaperone with the ferredoxin-like fold that binds Cu(I) via two Cys residues in a M(10)X(11)C(12)X(13)X(14)C(15) motif located in a solvent-exposed loop
  • important role, not only as a metallochaperone for delivering Cu to cuproenzymes, but also as a key player in maintaining the proper distribution and organization of Cu at the cellular level
  • transcription factor that upregulates prion protein expression, and intron 1 plays a key role in regulation of prion protein expression levels
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    text copper transport
    PATHWAY
    metabolism metal
    signaling
    a component
  • copper-ATOX1 complex
  • ability of ATOX1 to form a complex only with some domains of ATP7B is an interesting property of this class of proteins and may have a signaling role in the function of the ATPases
  • INTERACTION
    DNA
    RNA
    small molecule metal binding,
  • copper Cu2+
  • protein
  • interacting with ATP7B by its N-terminal metal-binding site 2 (key role in the transfer of copper from ATOX1)
  • interaction between ATOX1 and a metal-binding domain in ATP7A
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS