basic FUNCTION
| involved in the development of nervous system |
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playing an essential role in hair cell development |
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inducing regeneration of hair cells in deafness |
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may be functioning in the developing cochlea to initiate both inductive and inhibitory signals that regulate the overall formation of the sensory epithelia |
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activating E box-dependent transcription in collaboration with TCF3/E47 (being completely antagonized by the negative regulator of neurogenesis HES1) |
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may play a role in the differentiation of subsets of neural cells by activating E box- dependent transcription |
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playing a crucial role in intestinal cell differentiation |
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may contribute to granule neuron precursors proliferation |
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regulates the signal transduction pathway of sonic hedgehog |
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function of ATOH1 in postnatal cerebellar development |
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collaborates with the pro-proliferative GLI1-dependent transcriptional program to influence medulloblastoma development |
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BHLH transcription factor that specifies distinct neuronal subtypes of the proprioceptive pathway in mammals including the dI1 (dorsal interneuron 1) population of the developing spinal cord |
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involved in differentiation of neurons, secretory cells in the gut, and mechanoreceptors including auditory hair cells |
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its activity in the cochlea is both necessary and sufficient to drive auditory hair cell differentiation |
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essential for the intestinal goblet cell differentiation |
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activates proliferation within the normally postmitotic cochlear epithelium |
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governs the migration of postmitotic neurons that shape respiratory effectiveness at birth and chemoresponsiveness in adulthood |
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gene critical for hair cell differentiation |
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critical for promoting repair/regeneration of stereocilia and maintaining injured hair cells in the adult cochlea |
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PTF1A and ATOH1 are essential and sufficient for GABAergic versus glutamatergic specification in the neuroepithelium |
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