basic FUNCTION
| DNA damage response protein, that may affect the choice between competing base repair pathways in a manner that reduces the amount of substrates available for Ig gene conversion |
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DNA damage response protein that has been proposed to be a regulator and stabilizing co-factor of the ATM kinase |
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defines a novel NBS1-independent pathway of ATM signaling |
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SQ/TQ cluster domain-containing protein, acting as a lesion-specific focus scaffold in a Rad51-dependent pathway that resolves cytotoxic repair intermediates, most likely single-stranded DNA gaps, resulting from MLH1-dependent processing of base lesions |
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may function as structurally related scaffolds that facilitate efficient DNA repair, albeit with diverged lesion specificity |
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mediates ATM activation by oxidative stress, and thereby protects the aging brain by preventing accumulation of DNA damage |
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exert its developmental functions as a transcription factor |
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forms DNA damage-induced nuclear foci, and is required for cell survival, specifically in response to lesions repaired by the base excision repair pathway |
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in addition to its role in the DNA base damage response, has separate developmental functions as an essential regulator of respiratory organogenesis |
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function in DNA damage survival and in controlling the early stages of lung development |
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also contributes to neural tube development, but histologically other organs seemed to be developing normally |
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plays a key role in the auto-regulation of DYNLL1 levels |
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functioning as a sensor of DYNLL1 protein levels in a novel feedback mechanism for auto-regulated gene expression |
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key role in regulating the survival of developing B cells by activating DYNLL1 expression, which may then modulate BCL2L11-dependent apoptosis |
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transcription factor ATMIN (Asciz) is required for both lung tubulogenesis and ciliogenesis |
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ATMIN is critical for normal kidney development and mechanistically, ATMIN modifies Wnt signaling pathways |
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UBR5-mediated ATMIN ubiquitination is a vital event for ATM pathway selection and activation in response to DNA damage |
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mediates noncanonical ATM signaling in response to oxidative and replicative stress conditions |
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has multiple roles in different cell types, and its absence results in perturbed hematopoiesis, especially during stress conditions and aging |
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ATMIN is dispensable for ATM activation |
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encodes a cofactor required for activation of ATM kinase by replication stress |
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is a tumor suppressor in Lung adenocarcinoma |