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FLASH GENE
Symbol ATG7 contributors: mct - updated : 23-09-2016
HGNC name ATG7 autophagy related 7 homolog (S. cerevisiae)
HGNC id 16935
Location 3p25.3      Physical location : 11.314.009 - 11.599.132
Synonym name
  • APG7 autophagy 7-like (S. cerevisiae)
  • glucose-induced selective autophagy 7
  • ubiquitin-activating enzyme E1-like protein
  • APG7-like
  • ATG12-activating enzyme E1 ATG7
  • Synonym symbol(s) GSA7, APG7L, DKFZp434N0735, hAGP7, APG7-LIKE
    DNA
    TYPE functioning gene
    STRUCTURE 285.66 kb     19 Exon(s)
    regulatory sequence Promoter
    Binding site
    text structure
  • HSF1 regulates autophagy by directly binding to ATG7 promoter and transcriptionally up-regulating its expression
  • MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    19 - 5059 78 703 - 1999 10233149
    17 - 4819 - 623 - 1999 10233149
    18 - 4978 - 676 - 1999 10233149
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Nervousbrain    
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a FAP motif essential for the interaction of ATG7 with ATG3, but not for ATG7-homodimerization
  • HOMOLOGY
    interspecies ortholog to murine Apg7l
    homolog to S.cerevisiae Apg7
    Homologene
    FAMILY
  • ThiF family
  • ATG7 family
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    basic FUNCTION
  • ubiquitin activating enzyme E1-like protein, playing a necessary role in non-apoptotic death pathway
  • not required for initiation of autophagy but is required for bringing the opposing vacuolar membranes together for homotypic fusion, thereby completing peroxisome sequestration
  • autophagy protein, required for membrane trafficking and turnover in the axons
  • plays an important role in normal adipogenesis and inhibition of autophagy by disrupting ATG7 has a unique anti-obesity and insulin sensitization effect
  • involved in regulation of mitochondrial clearance during reticulocyte maturation
  • its activity may be dependent on the formation of a protein complex, and interaction between FOXO1 and ATG7 is a prerequisite for the formation of this protein complex
  • is an essential regulator of adult hematopoietic stem cells (HSCs) maintenance
  • is required for the TP53-dependent expression of CDKN1A (PMId: 22499945)
  • an effect of ATG7 unrelated to autophagy appears to modulate lysosomal photodamage
  • chronic morphine exposure caused ATG5 and ATG7-dependent and dopaminergic neuron-specific autophagy resulting in decreased neuron dendritic spines and the onset of addictive behaviors
  • ATG5- and ATG7-dependent autophagy of dopaminergic neurons contributed to cellular and behavioral responses to morphine
  • CELLULAR PROCESS protein
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
  • involved in ATG5/ATG7-dependent conventional pathway for macroautophagy
  • a component
  • ATG7ĚCASP9 complex performs a dual function of linking CASP9 to the autophagic process while keeping in check its apoptotic activity
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with BECN1 for autophagic death (induced by CASP8 inhibition)
  • interacting with FOXO1 (acetylated FOXO1 specifically interacts with ATG7 to induce the autophagic process)
  • interaction of ATG7 with TP53 (ATG7 and TP53 bind each other directly, and starvation increases this interaction, and in the absence of ATG7, cells fail to properly induce CDKN1A expression)
  • critical role for HSF1 in controlling cytoprotective autophagy through regulation of ATG7, which is distinct from the HSF1 function in the heat shock response
  • ATG7-induced CTSB overexpression contributes to an NLRP3-dependent proinflammatory response and subsequently impairs glucose-stimulated insulin secretion (GSIS) independently of apoptosis
  • PSMD10 was physically associated with ATG7 in the cytoplasm, and this association was enhanced by initial nutrient deprivation
  • role for SNAP23 in the control of macroautophagy and programmed cell death through an ATG9-dependent, but ATG7-independent, pathway regulating BAX protein levels and BAX activation
  • CNOT3 bound to and shortened the poly(A) tail of the mRNA encoding the key autophagy regulator ATG7
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional   deletion    
    resulted in profound muscle atrophy and age-dependent decrease in force
    Susceptibility to sporadic Parkinson disease (PD)
    Variant & Polymorphism other
  • variants, 11313449G>A, 11313811T>C, 11313913G>A and 11314041G>A, were identified only in PD patients
  • Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • mouse model with a targeted deletion of atg7 in adipose tissue, were slim and contained only 20p100 of the mass of white adipose tissue (WAT) found in wild-type mice
  • mice deficient for Atg5 or Atg7 specifically in the dopaminergic neurons were less sensitive to developing a morphine reward response, behavioral sensitization, analgesic tolerance and physical dependence compared to wild-type mice
  • genetic ablation of Atg7, but not Atg5, increased survival and partially restored cardiac function of Cnot1 or Cnot3 knockout mice