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Symbol ATG4B contributors: mct - updated : 12-06-2013
HGNC name ATG4 autophagy related 4 homolog B (S. cerevisiae)
HGNC id 20790
Location 2q37.3      Physical location : 242.577.026 - 242.613.264
Synonym name
  • cysteine endopeptidase AUT-like isoform 1
  • autophagin-1
  • cysteine protease ATG4B
  • AUT-like 1 cysteine endopeptidase
  • Synonym symbol(s) AUTL1, MGC1353, KIAA0943, APG4B
    EC.number 3.4.22.-
    DNA
    TYPE functioning gene
    STRUCTURE 36.25 kb     13 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    13 - 2892 44.3 393 - -
    isoform a
    13 splicing 2912 - 380 - -
    using an alternate splice site in the 3' coding region, compared to variant 1, resulting in a frameshift, the resulting isoform (b) is shorter and has a distinct C-terminus compared to isoform a
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Muscularstriatumskeletal  
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a conserved cysteine residue that is essential for the catalytic properties of these enzymes
  • a small alpha/beta-fold domain
  • HOMOLOGY
    Homologene
    FAMILY autophagin protein family
    CATEGORY enzyme , regulatory
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm
    basic FUNCTION
  • essential for cell homeostasis and cell remodeling during differentiation
  • required for processing GABARAPL2 for the latter to be conjugated to phosphatidylethanolamine on autophagosomal membranes, a key step in autophagosome biogenesis (
  • CELLULAR PROCESS protein, degradation
    PHYSIOLOGICAL PROCESS
    text cysteine proteinase involved in the autophagic process
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • MSTN increased in the expression of ATG4B, ULK2, with a trend to an increase in GABARAPL1 in cells treated with myostatin compared to control treated cells
  • RNF5 regulates basal levels of autophagy by controlling the stability of a select pool of the cysteine protease ATG4B
  • target gene of CEBPB and plays an important role in 3T3-L1 adipocyte differentiation
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • Atg4b-deficient mice showed a mild but measurable impairment of motor performance on the Rotarod (