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FLASH GENE
Symbol ATG4A contributors: - updated : 12-12-2005
HGNC name autophagy-related cysteine endopeptidase 2
HGNC id 16489
Location Xq22.1-q22.3      Physical location : 107.334.933 - 107.397.895
Synonym name
  • autophagin 2
  • AUT-like 2, cysteine endopeptidase (S. cerevisiae)
  • Synonym symbol(s) AUTL2, MGC43691, dJ889M15.3, APG4A
    DNA
    TYPE functioning gene
    STRUCTURE 62.00 kb     13 Exon(s)
    MAPPING cloned Y linked   status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    - - 2303 45.3 398 - Scherz-Shouval
    - - 2117 38.6 336 - Scherz-Shouval
    alternate in frame segment
    - - 1605 - 321 - Scherz-Shouval
    includes an alternate exon, compared to variant 1, that causes a frameshift and an early stop codon
    EXPRESSION
    Type widely
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Urinary     
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a conserved cysteine residue that is essential for the catalytic properties of these enzymes
  • HOMOLOGY
    Homologene
    FAMILY autophagin protein family
    CATEGORY enzyme
    SUBCELLULAR LOCALIZATION
    basic FUNCTION autophagic proteolysis
    CELLULAR PROCESS protein, degradation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS