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Symbol ATG3 contributors: np/mct - updated : 15-01-2011
HGNC name ATG3 autophagy related 3 homolog (S. cerevisiae)
HGNC id 20962
Location 3q13.2      Physical location : 112.251.359 - 112.280.485
Synonym name
  • autophagy Apg3p/Aut1p-like
  • APG3 autophagy 3-like (S. cerevisiae)
  • APG3-like
  • Synonym symbol(s) PC3-96, FLJ22125, MGC15201, DKFZp564M1178, APG3, APG3L
    EC.number 6.3.2.-
    DNA
    TYPE functioning gene
    STRUCTURE 29.13 kb     12 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    12 - 1372 - 314 - 2002 11825910
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart   highly
    Endocrineplacenta   highly
    Nervousbraindiencephalonhypothalamus  
    Urinarykidney   highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / Hematopoieticbone marrow   
    Muscularstriatumskeletal  
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Respiratoryalveolar cell type 2
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • (N)-terminal region plays a crucial role in GABARAPL2-PE (phosphatidylethanolamine) conjugation
  • a WEDL sequence that is a canonical AIM (Atg8 family interacting motif)
  • HOMOLOGY
    interspecies ortholog to murine Atg3
    Homologene
    FAMILY
  • ATG3 family
  • CATEGORY enzyme , regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria
    intracellular,cytoplasm,cytosolic
    basic FUNCTION
  • required for autophagocytosis, a starvation induced process responsible for an unspecific bulk transport of cytoplasmic proteins to the vacuole
  • facilitating the association of ATG12 and ATG5
  • E2-like enzyme necessary for GABARAPL2 lipidation during autophagy
  • role for ATG12-ATG3 in mitochondrial homeostasis and implicate the ATG12 conjugation system in cellular functions distinct from the early steps of autophagosome formation
  • E2-like enzyme that conjugates GABARAPL2 with phosphatidylethanolamine
  • CELLULAR PROCESS protein, degradation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component part of ATG12-ATG3 complex
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • substrate for ATG12 conjugation
  • directly interacts with GABARAPL2 through the WEDL sequence, which is distinct from canonical interaction between E2 and ubiquitin-like modifiers
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS