Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol ATG13 contributors: mct/npt/pgu - updated : 12-09-2018
HGNC name KIAA0652
HGNC id 29091
Location 11p11.2      Physical location : 46.638.825 - 46.696.367
Genatlas name autophagy-related protein 13
Synonym name
  • cDNA sequence,expressed in brain , 67kDa, related to C elegans 49.8 kDa protein
  • hypothetical protein LOC9776
  • Synonym symbol(s) FLJ20698, KIAA0652
    DNA
    TYPE functioning gene
    STRUCTURE 57.54 kb     18 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    18 - 4736 - 517 - 2009 19597335
    17 - 4625 52.7 480 - 2009 19597335
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Nervousbrain    
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a single LIR motif in ATG13 that interacts with human ATG8 homologues
  • conjugated RiboP
    HOMOLOGY
    interspecies homolog to C.elegans 49,8 kDa protein
    Homologene
    FAMILY
  • UPF0630 family
  • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    basic FUNCTION
  • ULK1-interacting phosphoprotein that is essential for macroautophagy
  • required for autophagy
  • with RB1CC1, act in concert during autophagy induction
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • part of ULK1-ATG13-RB1CC1 autophagy regulatory complex, phosphorylated by MTOR
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binding protein of ATG101
  • TAB2 also interacts with ATG13 and is phosphorylated by ULK1
  • its function is strictly depends on RB1CC1 binding, and has an additional function independent of ULK1/2 (with RB1CC1, act in concert during autophagy induction)
  • presence of an acidic residue adjacent to the core motif is crucial for the ability of ULK1 and ATG13 to interact with GABARAP
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS