basic FUNCTION
| with ATG2B, ATG5, ATG9B, are autophagy-related genes, having mononucleotide repeats with seven or more nucleotides |
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two ubiquitin-like conjugation systems, ATG12 and GABARAPL2 systems, which are tightly associated with expansion of autophagosomal membrane are required for autophagosome formation |
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ATG12-ATG5 conjugate has a novel E3-like activity for protein lipidation in autophagy |
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ATG5-ATG12 conjugate, a key regulator of the autophagic process, plays an important role in innate antiviral immune responses |
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ubiquitin-like modifier required for macroautophagy, has a single known conjugation target, another autophagy regulator called ATG5 |
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role for ATG12-ATG3 in mitochondrial homeostasis and implicate the ATG12 conjugation system in cellular functions distinct from the early steps of autophagosome formation |
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ATG12 conjugation system directs cellular functions distinct from the early steps of autophagosome formation |
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like ubiquitin and SUMO, may serve as a broad-based ubiquitin-like protein conjugation with far-reaching implications in biology and human disease |
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essential autophagy protein that is a positive mediator of mitochondrial apoptosis |
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MAP1LC3B, ATG5 and ATG12 are involved in mitochondrial quality control after oxidative damage, and to cellular longevity. |