Selected-GenAtlas references	SOURCE	GeneCards	NCBI Gene	Swiss-Prot	Ensembl
	HGNC	UniGene	Nucleotide	OMIM	UCSC

Home Page

FLASH GENE

Symbol

ATF7IP2

contributors: mct - updated : 12-11-2021

HGNC name	activating transcription factor 7 interacting protein 2
HGNC id	20397

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	16p13.2      Physical location : 10.522.724 - 10.577.494
Synonym name	MBD1-containing chromatin associated factor 2
Synonym symbol(s)	FLJ12668, MCAF2

DNA

TYPE	functioning gene
STRUCTURE	97.58 kb     12 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_024997 12 - 3659 NP_079273 - 682 - 2005 15691849 NM_001393719 14 - 3741 NP_001380648 - 682 - 2005 15691849 NM_001352120 13 - 3702 NP_001339049 - 682 - 2005 15691849 NM_001256160 12 - 3635 NP_001243089 - 543 - 2005 15691849

EXPRESSION

Type

widely

constitutive of

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive pharynx       highly   stomach       highly Reproductive male system testis     highly

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Connective adipose     highly

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

HOMOLOGY

Homologene

FAMILY

MCAF/AM-related proteins family

CATEGORY

transcription factor

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm
	intracellular,nucleus

basic FUNCTION	involved in transcriptional repression and heterochromatin formation
	might interact with some important partners by the conserved domain and be involved potentially in the transcription modulation during gonad development

CELLULAR PROCESS

nucleotide, transcription

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

complexing with MBD1, MCAF1,SETDB1 (facilitates the formation of heterochromatic domains, emphasizing the role of MCAF/AM family proteins in epigenetic control)

INTERACTION

DNA

RNA

small molecule

protein

ATF7IP and ATF7IP2 interact with MBD1, SETDB1, and Sp1 via two evolutionarily conserved distinct domains

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS