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FLASH GENE
Symbol ATF7IP2 contributors: mct - updated : 12-11-2021
HGNC name activating transcription factor 7 interacting protein 2
HGNC id 20397
Location 16p13.2      Physical location : 10.522.724 - 10.577.494
Synonym name MBD1-containing chromatin associated factor 2
Synonym symbol(s) FLJ12668, MCAF2
DNA
TYPE functioning gene
STRUCTURE 97.58 kb     12 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
12 - 3659 - 682 - 2005 15691849
14 - 3741 - 682 - 2005 15691849
13 - 3702 - 682 - 2005 15691849
12 - 3635 - 543 - 2005 15691849
EXPRESSION
Type widely
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestivepharynx   highly
 stomach   highly
Reproductivemale systemtestis  highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Connectiveadipose  highly
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
Homologene
FAMILY MCAF/AM-related proteins family
CATEGORY transcription factor
SUBCELLULAR LOCALIZATION     intracellular
intracellular,cytoplasm
intracellular,nucleus
basic FUNCTION
  • involved in transcriptional repression and heterochromatin formation
  • might interact with some important partners by the conserved domain and be involved potentially in the transcription modulation during gonad development
  • CELLULAR PROCESS nucleotide, transcription
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component complexing with MBD1, MCAF1,SETDB1 (facilitates the formation of heterochromatic domains, emphasizing the role of MCAF/AM family proteins in epigenetic control)
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • ATF7IP and ATF7IP2 interact with MBD1, SETDB1, and Sp1 via two evolutionarily conserved distinct domains
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS