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FLASH GENE
Symbol ATF7IP contributors: mct/pgu - updated : 13-09-2011
HGNC name activating transcription factor 7 interacting protein
HGNC id 20092
Location 12p13.31      Physical location : 14.518.610 - 14.651.696
Synonym name
  • MBD1-containing chromatin associated factor 1
  • ATFa-associated modulator
  • Synonym symbol(s) MCAF, p621, FLJ10139, FLJ10688, MCAF1, AM
    DNA
    TYPE functioning gene
    STRUCTURE 133.09 kb     15 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Physical map
    EMP1 12p12.3 epithelial membrane protein 1 FLJ33810 12p13.2 hypothetical protein FLJ33810 GRIN2B 12p12 glutamate receptor, ionotropic, N-methyl D-aspartate 2B ATF7IP 12p13.31 activating transcription factor 7 interacting protein FLJ22662 12p13.2 hypothetical protein FLJ22662 GUCY2C 12p12 guanylate cyclase 2C (heat stable enterotoxin receptor) HIST4H4 12p13.1 histone 4, H4 H2AFJ 12p12 H2A histone family, member J WBP11 12p13.1 WW domain binding protein 11 MGC47869 12p13.1 hypothetical protein MGC47869 LOC387843 12 hypothetical gene supported by AK092637 DO 12q13.2-q13.3 Dombrock blood group MGP 12p13-p12 matrix Gla protein FLJ32115 12p13.1 hypothetical protein FLJ32115 ARHGDIB 12p12.3 Rho GDP dissociation inhibitor (GDI) beta PDE6H 12p13 phosphodiesterase 6H, cGMP-specific, cone, gamma RERG 12p13.31 RAS-like, estrogen-regulated, growth-inhibitor LOC387844 12 hypothetical gene supported by AK093218 PTPRO 12p13-p12 protein tyrosine phosphatase, receptor type, O
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    15 - 4661 - 1270 - 2003 12665582
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Lymphoid/Immunethymus   highly
    Reproductivefemale systemuteruscervix highly
     male systemtestis  highly
    Respiratoryrespiratory tracttrachea  highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • AAA ATPase containing Von Willebrand factor type A (VWA) domain
  • many ser/thr-rich domain and repeats
  • two evolutionarily conserved domains directly interact with Sp1 and the general transcriptional apparatus
  • SUMO-interacting motifs (SIMs) that are composed of a hydrophobic core and a stretch of acidic AAs, playing an important role in the binding to SUMO3
  • HOMOLOGY
    interspecies ortholog to murine Atf7ip
    Homologene
    FAMILY MCAF/AM family proteins
    CATEGORY transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus
    basic FUNCTION
  • coactivator-like activity
  • negative or positive regulation of transcription in association with MBD1 or Sp1 proteins
  • required for transcriptional repression and heterochromatin formation by MBD1, together with the involvement of SETDB1
  • playing a role in epigenetic control
  • involved in Sp1-dependent maintenance of telomerase activity in cancer cells
  • may facilitates telomerase expression by Sp1, which may be a common mechanism in proliferative cancer cells
  • CELLULAR PROCESS nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component complexing with MBD1/SETDB1 (complex facilitating the formation of heterochromatic domains, and emphasizing the role of MCAF/AM family proteins in epigenetic control)
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacts with the transcriptional repression domain of MBD1 to form the repressive complex
  • interacts with SUMO2/3 and SUMO1, with a preference for SUMO2/3
  • ATF7IP and ATF7IP2 interact with MBD1, SETDB1, and Sp1 via two evolutionarily conserved distinct domains
  • a transcriptional positive regulator when coupled with Sp1
  • MBD1-MCAF interferes with Sp1-mediated transactivation
  • interact with SUMOs, which forms complexes with either the methyl-CpG-binding protein MBD1 or SETDB1, which trimethylates histone H3 at lysine 9 (H3-K9)
  • regulator of TERT expression
  • RSF1 and ATF7IP are very likely interacting with SP110 during the process of viral infections
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility to testicular germ cell tumor (TGCT)
    Variant & Polymorphism other
  • association between genetic marker rs4617646 and TGCT risk
  • Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS