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FLASH GENE
Symbol ATF7 contributors: mct - updated : 31-05-2016
HGNC name activating transcription factor 7
HGNC id 792
Location 12q13.13      Physical location : 53.905.844 - 54.020.199
Synonym symbol(s) ATFA
DNA
TYPE functioning gene
STRUCTURE 118.56 kb     12 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
12 - 6641 - 462 - 2011 21858082
12 - 6704 - 483 - 2011 21858082
- - 867 - 117 - 2011 21858082
  • ATF7-4
  • is an important cytoplasmic negative regulator of ATF7 and ATF2 transcription factors
  • - - 776 - 117 - 2011 21858082
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestivepharynx   highly
     salivary gland   highly
    Lymphoid/Immunelymph node   moderately
    Reproductivefemale systemuteruscervix  
     male systemprostate   
    Urinarybladder   highly
     kidney    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / hematopoieticbone marrow  moderately
    Connective   moderately
    Muscularstriatumskeletal  
    Nervouscentral   
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES basic
    STRUCTURE
    motifs/domains
  • a consensus sumoylation motif (IKEE), located within the N-terminal activation domain
  • a C2H2-type zinc finger domain
  • a conserved basic leucine zipper (bZIP) domain
  • conjugated PhosphoP , sumoylated , Other
    mono polymer heteromer , dimer
    HOMOLOGY
    interspecies homolog to rattus Atf7 (96.4 pc)
    homolog to murine Atf7 (97.3 pc)
    intraspecies homolog to ATF4
    homolog to ATF2
    Homologene
    FAMILY
  • BZIP family
  • cyclic AMP responsive binding protein (CREB)/activating transcription factor (ATF) family of transcription factors
  • CATEGORY regulatory , DNA associated , transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus,nucleoplasm
    intracellular,nucleus,chromatin/chromosome,euchromosome
    basic FUNCTION
  • transcriptional activation
  • may have a critical role in gene expression induced by social isolation stress
  • ATF7 and DMRT2 play key roles in paternal stress-induced telomere shortening in the offspring
  • CELLULAR PROCESS nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • heterodimerizing with other ATF
  • heterodimerize with JUN or FOS proteins and its transcriptional activity is mediated by interaction with TAF12, a subunit of the general transcription factor TFIID
  • INTERACTION
    DNA binding to cAMP responsive element
    RNA
    small molecule metal binding,
  • Zn2+
  • protein
  • with PRL1 protein tyrosine phosphatase
  • binds to CRE elements within specific promoters
  • TAF12, a component of the TFIID general transcription factor, mediates ATF7 transcriptional activity through direct interactions between the two proteins
  • ATF7 silences the transcription of HTR5B by directly binding to its 5prime-regulatory region, and mediates histone H3-K9 trimethylation via interaction with the ESET histone methyltransferase
  • ATF7 interacts with TAF12 and contributes to the hypersensitivity of Osteoclast (OCL) precursors to 1,25-(OH)&
  • 8322;D&
    8323; in in Paget disease
    cell & other
    REGULATION
    activated by stress and growth factors that activate ATF2 and ATF7 mainly via sequential phosphorylation of two conserved threonine residues in their activation domain
    induced by the adenovirus E1a13S mRNA product
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • Atf-7-deficient mice exhibit abnormal behaviours and increased 5-HT receptor 5B (Htr5b) mRNA levels in the dorsal raphe nuclei