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FLASH GENE
Symbol ATF6B contributors: mct - updated : 12-10-2011
HGNC name activating transcription factor 6 beta
HGNC id 2349
Location 6p21.3      Physical location : 3.362.220 - 32.096.017
Synonym name
  • major histocompatibility class III region, G13 (see HTFAG@)
  • cAMP responsive element binding protein-like 1
  • Synonym symbol(s) CREBRP, DADB-220I18.4, CREB-RP, CREBL1, FLJ10066, G13
    DNA
    TYPE like-sequence
    SPECIAL FEATURE opposite orientation
    text
  • including three alternative 5' parts of TNXB
  • STRUCTURE 12.97 kb     18 Exon(s)
    MAPPING cloned Y linked N status confirmed
    Map pter - CYP21A2 CYP21A2 /TNXB /CREBL1 - HLA-DRA - HLA-DRB1 - cen
    Authors Min (95)
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    18 - 2613 - 700 - 2004 14973138
    17 - 2622 - 703 - 2004 14973138
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • basic leucine zipper (bZIP) protein
  • five evolutionarily conserved N-linked glycosylation sites
  • conjugated GlycoP
    HOMOLOGY
    Homologene
    FAMILY
    CATEGORY transcription factor
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    intracellular,nucleus
    basic FUNCTION
  • endogenous ATF6B moderated ER stress-response gene induction
  • may serve as a transcriptional repressor functioning in part to regulate the strength and duration of ATF6-mediated ER stress-response gene activation during the ER stress response
  • ATF6 and ATF6B, are cleaved during the ER stress response (ERSR)
  • relative levels of ATF6 and ATF6B, may contribute to regulating the strength and duration of ATF6-dependent ERSR gene induction and cell viability
  • key transcriptional repressor of ATF6, which contribute to regulating the strength and duration of ATF6-dependent ER stress response (ERSR) gene induction
  • unglycosylated ATF6B may directly facilitate the expression of ERSR genes by losing its repressor function to ATF6
  • CELLULAR PROCESS nucleotide, transcription
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA binding to cAMP response element
    RNA
    small molecule
    protein
  • cellular protein that interacts with the NS4B protein of hepatitis C virus
  • host cellular target of the Toxoplasma gondii virulence factor ROP18
  • cell & other
    REGULATION
    activated by activated in response to ER stress
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS