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Symbol ATF5 contributors: mct/pgu - updated : 05-03-2018
HGNC name activating transcription factor 5
HGNC id 790
Location 19q13.33      Physical location : 50.431.958 - 50.437.193
Synonym name transcription factor ATFx
Synonym symbol(s) ATFX, ATF-7, FLJ34666, HMFN0395
TYPE functioning gene
STRUCTURE 5.23 kb     3 Exon(s)
10 Kb 5' upstream gene genomic sequence study
regulatory sequence Promoter
Binding site   transcription factor
text structure
  • the region -105 to +3 relative to the transcription start site is that having promoter activity, and contained potential binding sites for several transcription factors, including EBF1, Sp1 and E2F1
  • MAPPING cloned Y linked N status confirmed
    TRANSCRIPTS type messenger
    text two alternative 5'-untranslated regions (5'-UTRs), 5'-UTRalpha and 5'-UTRbeta, derived from exon1alpha and exon1beta (PMID: 18055463)
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    3 - 2088 30.5 282 - 2008 18055463
    4 - 2293 - 282 - 2008 18055463
    - - 2059 - 282 - 2008 18055463
       expressed in (based on citations)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveliver   highly
     salivary gland   moderately
    Nervousbrainhindbraincerebellum   Homo sapiens
    Olfactory (smell)olfactory bulb     Homo sapiens
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Epithelialbarrier liningneuroepithelium   Homo sapiens
    SystemCellPubmedSpeciesStageRna symbol
    Nervousneuron Homo sapiens
    NervousPurkinje cell Homo sapiens
    Olfactoryolfactory receptor Homo sapiens
    cell lineage
    cell lines
    fluid/secretion predominantly in lymph
    at STAGE
    physiological period embryo
  • highly expressed in embryonic olfactory sensory neurons (OSNs)
  • expressed by proliferating cerebellar granule neuron progenitor cells, in both the embryonic and postnatal cerebellar external granule layer (EGL) and in the rhombic lip, the embryonic structure from which the EGL arises
  • two N-terminal consensus MAP kinase phosphorylation sites
  • N-terminal hydrophobic amino acids play an important role in the regulation of ATF5 protein expression in IL1B-mediated immune response
  • a C-terminal bZIP motif with only 3 leucines instead of the conventional 5 (the 2 distal leucines are replaced by valines)
  • conjugated sumoylated
    mono polymer dimer
    interspecies homolog to rattus Atf5 (88.9 pc)
    homolog to murine Atf5 (87.5 pc)
  • basic-leucine zipper (BZIP) family
  • ATF/cAMP response element-binding family of transcription factors
  • CATEGORY regulatory , DNA associated , transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    basic FUNCTION
  • acting as a transcriptional activator
  • playing a major regulatory role in the regulation of the transition of neuroprogenitor cells to postmitotic neurons in brain development (blocking the differentiation of neuroprogenitor cells into neurons)
  • promoting degradation of KAT5
  • required for the survival of cancer cells but not for noncancer cells
  • regulates BCL2 mRNA abundance primarily at the transcription level
  • critically involved, often in a cell type-dependent manner, in cell survival, proliferation, and differentiation
  • regulates cancer cell survival in a cell type-specific manner
  • critical regulator of cell proliferation and survival
  • promotes proliferation of cerebral cortical neuroprogenitor cells and its down regulation permits their differentiation
  • role for ATF5 in the regulation of osteogenic differentiation in adipose-derived stem cells
  • is required for terminal differentiation and survival of olfactory sensory neurons
  • controls the centriole-pericentriolar material(PCM) interaction in a cell-cycle- and centriole-age-dependent manner
  • is an essential structural protein that is required for the interaction between the mother centriole and the PCM
  • mammalian cells require ATF5 to maintain mitochondrial activity during mitochondrial stress and promote organelle recovery
  • cellular prosurvival transcription factor within the basic leucine zipper (bZip) family that is involved in cellular differentiation and promotes cellular adaptation to stress
  • have a critical cell cycle-dependent structural function at the centrosome
  • ATF5 SUMOylation is an essential mechanism that regulates ATF5 localization and function at the centrosome
  • CELLULAR PROCESS cell life, antiapoptosis
    nucleotide, transcription, regulation
    text cell cycle control
    a component
  • central role for the ATF5/EP300 complex in ATF5 function, suggesting that coordinated actions by ATF5, EP300, ELK1, and ERK/mitogen-activated protein kinase (MAPK) are essential for ATF5-dependent EGR1 activation and cell proliferation and survival
    DNA binding to the cAMP response element (cre) consensus 5' GTGACG(A/C)(A/G) 3'a sequence present in many viral and cellular promoters
    small molecule
  • binding to GABAB receptor, GABBR1 and PRL1
  • interacting with CCND3
  • potent repressor of TP53 and elevated expression of ATF5 in a tumor may relate to enhanced malignant phenotypes, such as radioresistance or greater cell motility
  • EBF1 transcription factor binds to the ATF5 promoter and regulates the ATF5
  • BCL2 is a downstream target of ATF5 that mediates the prosurvival function of ATF5 in C6 glioma cells
  • BCR-ABL1 suppresses autophagy through ATF5-mediated regulation of MTOR transcription
  • reciprocal interaction between ATF5 and SHH in which SHH stimulates ATF5 expression and in which ATF5 contributes to SHH-stimulated cerebellar granule neuron progenitor cells expansion
  • ATF5 was also found to be a target of CEB3L2 in chondrocytes
  • DDIT3 induces ATF5 to trigger apoptosis in response to perturbations in protein homeostasis, and both ATF5 and DDIT3 have proapoptotic functions
  • cell & other
    Other transcriptional activity enhanced by CCND3 and slightly inhibited by CDK4
    protein expression increased by cisplatin via preventing the ubiquitin-dependent degradation
    SUMOylation of ATF5 is elevated in the G1 phase of the cell cycle and diminished in the G2/M phase
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral   LOH    
    cause apoptotic cell death in glioblastoma and breast cancer cells
    constitutional     --over  
    within the characteristic polyglutamine-containing neuronal nuclear inclusions in brains of Huntington patients
    Variant & Polymorphism
    Candidate gene
    Therapy target
    neurologyneurodegenerativehuntington chorea
    ATF5-increasing interventions might have therapeutic potential for HD
  • Atf5(-/-) pups die neonatally, which is consistent with an olfactory defect resulting in a competitive suckling deficit