basic FUNCTION
| acting as a transcriptional activator |
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playing a major regulatory role in the regulation of the transition of neuroprogenitor cells to postmitotic neurons in brain development (blocking the differentiation of neuroprogenitor cells into neurons) |
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promoting degradation of KAT5 |
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required for the survival of cancer cells but not for noncancer cells |
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regulates BCL2 mRNA abundance primarily at the transcription level |
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critically involved, often in a cell type-dependent manner, in cell survival, proliferation, and differentiation |
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regulates cancer cell survival in a cell type-specific manner |
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critical regulator of cell proliferation and survival |
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promotes proliferation of cerebral cortical neuroprogenitor cells and its down regulation permits their differentiation |
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role for ATF5 in the regulation of osteogenic differentiation in adipose-derived stem cells |
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is required for terminal differentiation and survival of olfactory sensory neurons |
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controls the centriole-pericentriolar material(PCM) interaction in a cell-cycle- and centriole-age-dependent manner |
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is an essential structural protein that is required for the interaction between the mother centriole and the PCM |
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mammalian cells require ATF5 to maintain mitochondrial activity during mitochondrial stress and promote organelle recovery |
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cellular prosurvival transcription factor within the basic leucine zipper (bZip) family that is involved in cellular differentiation and promotes cellular adaptation to stress |
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have a critical cell cycle-dependent structural function at the centrosome |
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ATF5 SUMOylation is an essential mechanism that regulates ATF5 localization and function at the centrosome |