| component of the PERK pathway involved in the unfolded protein response (UPR), a process that protects cells from the negative consequences of endoplasmic reticulum (ER) stress  |
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EIF2AK4-ATF4 pathway is critical for maintaining metabolic homeostasis in tumour cells, making it a novel and attractive target for anti-tumour approaches  |
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EIF2AK4/ATF4 pathway is involved in this regulation through the presence of an AARE in NUPR1 promoter  |
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cell-autonomous role of ATF4 in chondrocytes dominates the role of ATF4 in osteoblasts during development for the control of early osteogenesis and skeletal growth  |
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new cellular pathway in which ATF4 regulates the expression of ARHGDIA that in turn affects Rho GTPase protein levels, and thereby, controls cellular functions as diverse as memory and cell motility  |
protein
| GPE1-binding protein, GPE1-BP ( |
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TATA-binding protein, TFIIB, the RAP30 subunit of TFIIF and the coactivator CREB-binding protein ( |
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ZIP kinase  |
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forms a heterodimer with the bZIP domain of C/EBP beta ( |
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transcription factor 11 (basic leucine zipper type), TCF11 ( |
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GABAB receptor ( |
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SKP1 interacting partner 3, SKIP3 ( |
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Disrupted-In-Schizophrenia 1, DISC1 ( |
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subunit 3 of RNA polymerase II, RPB3 ( |
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Zhangfei, ZF ( |
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p300/CBP-associated factor, PCAF ( |
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activating transcription factor 3, ATF3 ( |
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transcription factor of the unfolded protein response (UPR) that binds to a specific CREB/ATF site within the parkin (PARK2)promoter  |
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interaction with PTH (bone formation stimulated by PTH is in part mediated by ATF4)  |
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may be a down stream target of FGF2 signaling in osteoblasts  |
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necessary for the regulation of NUPR1 expression during leucine starvation  |
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TWIST1, TWIST2 are novel inhibitory binding partners of ATF4  |
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is a protein interacting with EGLN2 as well as EGLN3, but not with EGLN1  |
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functional interaction between ATF4, TXLNG, and NACA, three proteins that have been previously shown to associate using various protein-protein interaction assays  |
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FOXO1 physically interacts with and promotes the transcriptional activity of ATF4 (FOXO1 and ATF4 cooperate to increase glucose levels and decrease glucose tolerance)  |
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ATF4 activates BGLAP in osteoblasts and indian hedgehog (IHH) in chondrocytes  |
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transcriptional repressor of ATF4 during UV stress (binds to critical elements in the ATF4 promoter, resulting in its transcriptional repression)  |
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VIM, a leucine zipper-containing intermediate filament protein, suppresses ATF4-dependent osteocalcin (OCN) transcription and osteoblast differentiation  |
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FAM175B interaction with ATF4 is necessary and essential for the cytoprotective function of FAM175B following oxidative stress  |
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APLN is down-regulated by ATF4 via the pro-apoptotic MAPK14 pathway under endoplasmic reticulum (ER) stress  |
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TBL2 interacts with PKR-like ER-resident kinase (EIF2AK3), and under ER stress, it mediates protein expression of activating transcription factor 4 (ATF4)  |
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under ER stress, TBL2 participates in ATF4 translation through its association with the mRNA  |
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role of ATF4 in the SESN2 gene upregulation induced by mitochondrial dysfunction  |
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ATF4 could maintain SREBF1 protein stability by directly activating the expression of USP7 which deubiquitinates SREBF1 and increases its protein content in cell  |
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chenodeoxycholic acid (CDCA) regulation of FGF21 transcription is mediated at least partially by an EIF2A-dependent increase in ATF4 expression  |
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beneficial role of hypothalamic ATF4/ATG5 axis in the regulation of energy expenditure, obesity, and obesity-related metabolic disorders  |