basic FUNCTION
| may be playing a role in the endothelial cell death associated with atherogenesis |
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repressing MMP2 expression by antagonizing TP53 dependent transactivation of the collagenase promoter |
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negative regulator of IL6 and IL12b transcription by altering chromatin structure, thereby restricting access to transcription factors |
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seems to regulate TLR4-stimulated inflammatory responses as part of a negative-feedback loop |
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stress-activated regulator of TP53 protein stability/function providing the cell with a means of responding to a wide range of environmental insult, thus maintaining DNA integrity and protecting against cell transformation |
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repressor of the NFE2L2-directed stress response pathway ( |
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acts within natural killer cells to regulate antiviral responses ( |
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plays a pleiotropic role in determining cell fate in response to mitogenic or stress stimuli |
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ATF3 and OEATC1 are potentially novel gatekeepers of genomic integrity after UV exposure (Pubmed 19219066) |
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adaptive-response gene, induced by various stress signals relevant to T2D, such as high glucose and high fatty acid and proapoptotic in beta-cells |
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regulates proliferation or apoptosis under stress conditions by down or upregulation of related genes |
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promotes human Th1 differentiation |
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key role for ATF3 in regulating mast cell survival and mediator release |
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plays a key role in a mechanism defending against human papillomavirus-induced carcinogenesis |
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negatively regulates the expression of adiponectin and ADIPOR2, and downregulates ADIPOR1 expression |
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negatively regulates ADIPOR1 expression via binding to an ATF3-responsive region in the promoter, which plays an important role in attenuation of adiponectin signaling and induction of insulin resistance |
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plays a critical role in the development of insulin resistance in obesity and type 2 diabetes |
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negatively regulates the expression of both adiponectin and ADIPOR2, and may contribute to the development of insulin resistance or type 2 diabetes through attenuation of adiponectin signaling |
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protects cultured hippocampal neurons from apoptosis and extrasynaptic NMDA receptor-induced cell death triggered by bath application of NMDA or oxygen-glucose deprivation |
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plays a role in hyperglycemia or hyperlipidemia-mediated downregulation of PDX1 expression |
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can contribute to hyperglycemia or hyperlipidemia-mediated suppression of PDX1, lead to impaired insulin biosynthesis |
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role of ATF3 as an essential co-transcription factor for TP53 upon DNA damage |
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plays an important role in the dysfunction of beta-cells induced by chronic ER stress |
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inhibits PDX1-mediated transactivation through the inhibition of EP300-stimulated coactivation, which may lead to beta-cell dysfunction by ER stress |
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stress-adaptive gene that regulates proliferation or apoptosis under stress conditions |
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may contribute to the inhibition of adipocyte differentiation in hypoxia through downregulation of CEBPA expression |
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stress-induced ATF3 acts as a crucial inhibitor of adipocyte differentiation |
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is a novel repressor of androgen signaling that can inhibit AR functions, allowing prostate cells to restore homeostasis and maintain integrity in the face of a broad spectrum of intrinsic and environmental insults |
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ATF3 may play a role in adipocyte hypoxia-mediated mitochondrial dysfunction in obesity |
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hypoxia-inducible transcription factor that contributes to repression of adiponectin expression and inhibition of adipocyte differentiation, which are adipocyte dysfunctions induced by adipocyte hypoxia in obesity |
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may be involve in adipocyte hypoxia-mediated mitochondria dysfunction |
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ATF3 plays an important role in the control of glucose and energy metabolism by regulating AGRP |
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regulator in myeloid cells that enhances breast cancer metastasis and has predictive value for clinical outcomes |
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dichotomous role for ATF3-mediated regulation of neutrophilic responses: inhibition of neutrophil chemokine production but promotion of neutrophil chemotaxis |
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has neuroprotective action against cerebral ischemia, which may involve caspase 3 |
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ATF3-mediated inhibition of PPARG expression may contribute to inhibition of adipocyte differentiation during cellular stress including ER stress |