Selected-GenAtlas references | SOURCE | GeneCards | NCBI Gene | Swiss-Prot | Ensembl |
HGNC | UniGene | Nucleotide | OMIM | UCSC |
Home Page |
FLASH GENE |
Symbol | ATF2 | contributors: mct/pgu - updated : 12-07-2017 |
HGNC name | activating transcription factor 2 |
HGNC id | 784 |
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Location | 2q31.1 Physical location : 175.939.007 - 176.032.897 |
Synonym name | |
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Synonym symbol(s) | CREB2, HB16, CREBP1, MGC111558, TREB7, CRE-BP1 |
DNA |
TYPE | functioning gene |
STRUCTURE | 93.90 kb 14 Exon(s) |
10 Kb 5' upstream gene genomic sequence study |
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MAPPING | cloned | Y | linked | N | status | confirmed |
RNA |
TRANSCRIPTS | type | messenger |
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EXPRESSION |
Type | ubiquitous |
expressed in | (based on citations) | ||||||||||||||||||||||||||||||||||||||||
organ(s) |
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tissue |
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cell lineage
cell lines
| fluid/secretion
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at STAGE |
PROTEIN |
PHYSICAL PROPERTIES
STRUCTURE
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motifs/domains
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mono polymer | homomer , heteromer , dimer |
HOMOLOGY |
interspecies | homolog to murine Atf2 |
intraspecies | homolog to ATF7 |
Homologene |
FAMILY | |
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CATEGORY | regulatory , transcription factor |
SUBCELLULAR LOCALIZATION | intracellular |
intracellular,cytoplasm,cytosolic | |
intracellular,nucleus,chromatin/chromosome |
basic FUNCTION | |
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CELLULAR PROCESS | nucleotide, transcription |
PHYSIOLOGICAL PROCESS |
PATHWAY |
metabolism |
signaling |
a component |
INTERACTION |
DNA | binding |
RNA |
small molecule |
protein | |
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cell & other |
REGULATION |
activated by | virus |
mitogen activated protein kinase (MAPK) pathways | |
stress and growth factors that activate ATF2 and ATF7 mainly via sequential phosphorylation of two conserved threonine residues in their activation domain |
inhibited by | polyamines (negatively regulate ATF2 expression posttranscriptionally and polyamine depletion stabilizes ATF2 mRNA by enhancing the interaction of the 3prime-untranslated region (UTR) of ATF2 with cytoplasmic ELAVL1) |
Other | phosphorylated by MAPK14/Jun NH2-terminal protein kinase |
phosphorylated at Serine 121 by protein kinase C (controls c-Jun-mediated activation of transcription) | |
the MEKK/MKK7/JNK2 module is responsible for ATF2 phosphorylation |
ASSOCIATED DISORDERS |
corresponding disease(s) |
Other morbid association(s) |
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Susceptibility |
Variant & Polymorphism
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Candidate gene
Marker
| Therapy target
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ANIMAL & CELL MODELS |