Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol ATAT1 contributors: mct - updated : 14-05-2014
HGNC name alpha tubulin acetyltransferase 1
HGNC id 21186
Location 6p22.1      Physical location : -
Synonym name
  • chromosome 6 open reading frame 134
  • putative protein product of Nbla00487
  • hypothetical protein LOC79969
  • Synonym symbol(s) FLJ13158, DAQB-47P19.10, C6orf134, Em:AB023049.7, MEC17, TAT
    EC.number 2.3.1.108
    DNA
    TYPE functioning gene
    STRUCTURE 19.99 kb     13 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    13 - 1740 - 409 - 1997 9373149
    11 - 2195 - 323 - 1997 9373149
    9 - 2875 - 288 - 1997 9373149
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestivemouth   highly
    Endocrineadrenal gland   highly
    Nervousbrainforebraincerebral cortex highly Rattus norvegicusFetal
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a catalytic domain (AAs 1193)
  • an unstructured tail (AAs 193421)
  • AP2-binding region (AAs 307387) pulled down full-length alpha-adaptin and a truncated variant lacking the appendage domain (AAs 1690), but not a construct missing both the hinge and appendage domains (AAs 1620)
  • HOMOLOGY
    Homologene
    FAMILY
  • UPF0635 family
  • CATEGORY enzyme , motor/contractile
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria
    intracellular,cytoplasm,cytoskeleton,microtubule,mitotic spindle
    text
  • colocalizes on bundled microtubules with doublecortin
  • localizes to clathrin-coated pits (CCPs) through a direct interaction with AP2 that is required for microtubule acetylation
  • basic FUNCTION
  • enzyme that acetylates the K40 residue of alpha-tubulin, the only post-translational modifications known to occur on the luminal surface of microtubules
  • could acetylate another protein, or act as a MAP, possibly inside the microtubule lumen
  • having a highly specific alpha-tubulin K40 acetyltransferase activity and a catalytic preference for microtubules over free tubulin
  • promotes rapid ciliogenesis and efficient mechanosensation
  • required for the acetylation of axonemal microtubules and for the normal kinetics of primary cilium assembly
  • balance of acetylation and deaceylation by ATAT1/HDAC6 enzymes with opposite activities regulates the migratory and invasive capacities of breast tumor cells
  • importance of ATAT1 and alpha-tubulin acetylation in cortical development
  • has an overall fold similar to the KAT2A histone acetyltransferase but contains a relatively wide substrate binding groove and unique structural elements that play important roles in alpha-tubulin-specific acetylation
  • has a conserved function as the major alpha-tubulin acetyltransferase in ciliated organisms and has an important role in regulating subcellular specialization of subsets of microtubules
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • ATAT1 tubulin acetyltransferase binds and regulates cortactin acetylation levels
  • interaction of ATAT1 with AP2A1, AP2A2, AP2B1, AP2M1 is required for directional migration
  • EP300 negatively regulates ATAT1 expression and is sequestered on microtubules upon stress
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • Atat1-null mices display no overt phenotypes, alpha-tubulin acetylation is lost in sperm flagella and the dentate gyrus is slightly deformed