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FLASH GENE
Symbol ATAD5 contributors: mct/pgu - updated : 09-09-2014
HGNC name ATPase family, AAA domain containing 5
HGNC id 25752
Location 17q11.2      Physical location : 29.159.022 - 29.222.295
Synonym name
  • chromosome fragility associated gene 1
  • chromosome 17 open reading frame 41
  • enhanced level of genomic instability 1 homolog
  • Synonym symbol(s) FLJ12735, FRAG1, C17orf41, ELG1
    DNA
    TYPE functioning gene
    STRUCTURE 69.60 kb     23 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    23 - 6245 - 1844 - 2005 15983387
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Lymphoid/Immunelymph node    
     spleen    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / hematopoieticbone marrow   
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • N-terminus contributes to the maintenance of genome stability, and that one function of this N-terminus is to promote the nuclear localization
  • three small ubiquitin-like modifier (SUMO)-interacting motifs and a PCNA-interacting protein box close to the N-terminus
  • a Walker A motif in the conserved RFC region that is dispensable for ATAD5 function
  • an unique C-terminus mediates oligomerization with Rfc2-5, nuclear import, and chromatin association, and is critical for its function
  • HOMOLOGY
    intraspecies homolog to replication factor C
    Homologene
    FAMILY
  • AAA ATPase family
  • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,chromatin/chromosome
    text with CHTF18 localize to chromatin and ATAD5 plays a role in the recruitment of CHTF18
    basic FUNCTION
  • regulator of genomic integrity
  • playing a central role in determining whether DNA damage is compatible with cell survival or whether it requires cell elimination by apoptosis
  • encodes a Replication Factor C (RFC) homolog that is important for the maintenance of genome stability
  • plays a role in the suppression of spontaneous DNA damage in addition to its previously identified roles in the resistance to DNA damage
  • plays an important role in S phase to preserve genomic stability
  • would be a new member of proteins involved in maintenance of genomic integrity
  • importance of ATAD5 and SUMOylated PCNA in the maintenance of genomic stability
  • with WDHD1, and CHTF18 may coordinate the relative movement of the replication fork with respect to the cohesin ring
  • specifically directs USP1-WDR48 complex for PCNA deubiquitination
  • may be important for suppression of genomic instability, and loss-of-function mutations are sufficient to cause genomic instability and tumorigenesis
  • regulates the lifespan of replication factories
  • is required for the regulation of chromatin-bound PCNA levels
  • has an important role in maintaining chromosome integrity by regulating PCNA levels on chromatin, thereby acting as a PCNA unloading factor
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • complex ATAD5-RFC2-RFC5 functions in a fundamental DNA metabolism to suppress genomic instability
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • associating with RAD9A (involved in the BCL2 pathway)
  • interacting partner for the USP1 (ubiquitin-specific protease 1)-WDR48 complex, a deubiquitinating enzyme complex for PCNA and FANCD2
  • interacts with PCNAs that are localized at stalled replication forks
  • interaction with BRD4 through its extraterminal (ET) domain
  • plays a role in PCNA deubiquitination
  • regulates the cycle of DNA replication factories, probably through its PCNA-unloading activity
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS