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FLASH GENE
Symbol ATAD3B contributors: mct - updated : 16-11-2016
HGNC name ATPase family, AAA domain containing 3B
HGNC id 24007
Location 1p36.33      Physical location : 1.407.163 - 1.431.581
Synonym name AAA-ATPase TOB3
Synonym symbol(s) TOB3, KIAA1273, AAA-TOB3
DNA
TYPE functioning gene
SPECIAL FEATURE arranged in tandem
text ATAD3A and ATAD3B, are located in tandem on chromosome 1p36.33
STRUCTURE 24.42 kb     16 Exon(s)
MAPPING cloned   linked   status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
16 - 2466 67 648 - 2008 18639545
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart     Homo sapiensAdult
Digestiveintestinesmall intestine  highly
 intestinelarge intestinecolon moderately
Nervousbrain     Homo sapiensAdult
Reproductivefemale systemplacenta    Homo sapiensFetal
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Connectivebone   
Muscularstriatumskeletal   Homo sapiensFetal
cell lineage in adult germinative zone
cell lines in astrocytoma cell lines but not expressed in oligodendroglioma cell lines
fluid/secretion
at STAGE
physiological period embryo
Text expressed in embryonic tissues
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
intraspecies paralog to ATAD3A
paralog to ATAD3C
Homologene
FAMILY
  • AAA+ ATPase ATAD3 protein family
  • CATEGORY enzyme , transport
    SUBCELLULAR LOCALIZATION
    basic FUNCTION
  • having a role in tumor progression
  • potential for ATAD3B as a putative marker in discriminating astrocytomas from oligodendrogliomas
  • has displacement loop binding properties and is involved in mitochondrial nucleoid organization
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS exocytosis transport
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule nucleotide,
  • ATP binding
  • protein
  • ATAD3B is a negative regulator of ATAD3A and may function as an adaptor of mitochondrial homeostasis and metabolism in hESCs and cancer cells
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS