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FLASH GENE
Symbol ASUN contributors: mct - updated : 17-12-2015
HGNC name asunder spermatogenesis regulator
HGNC id 20174
Location 12p11.23      Physical location : -
Genatlas name granulosa cell tumorigenesis gene 1
Synonym name
  • chromosome 12 open reading frame 11
  • Synonym symbol(s) GCT1, C12orf11, Mat89Bb, NET48, SPATA30
    DNA
    TYPE functioning gene
    STRUCTURE 33.14 kb     17 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    17 - 2988 - 706 - 2012 23097494
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveesophagus   highly
    Reproductivefemale systemovary   
     male systemtestis   
    Urinarybladder   highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / hematopoieticbone marrow  highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    Homologene
    FAMILY
    CATEGORY protooncogene
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus
    basic FUNCTION
  • regulator of dynein localization and centrosome positioning during spermatogenesis
  • its down-regulation causes reduction of perinuclear dynein in prophase of mitosis
  • promotes dynein recruitment and centrosomal tethering to the nucleus at mitotic entry
  • essential for recruitment of dynein motors to the nuclear envelope (NE) and nucleus-centrosome coupling at the onset of cell division
  • is a potential critical regulator of dynein localization and dynein-mediated processes during oogenesis
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component functional component of Integrator (INT), a multisubunit complex required for 3'-end processing of small nuclear RNAs
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • PAFAH1B1 is a strong dominant enhancer of ASUN and localization of PAFAH1B1 in male germ cells is ASUN dependent (PMID;
  • controls dynein localization via a mechanism distinct from that of either BICD2 or CENPF
  • interacts with dynein in the cytoplasm via PAFAH1B1
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    testicular seminomas
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS