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FLASH GENE
Symbol ASPN contributors: mct - updated : 17-08-2007
HGNC name asporin
HGNC id 14872
Location 9q22      Physical location : 95.218.488 - 95.244.844
Synonym name
  • periodontal ligament associated protein 1
  • asporin (LRR class 1)
  • asporin proteoglycan
  • small leucine-rich protein 1C
  • Synonym symbol(s) FLJ20129, PLAP1, SLRR1C
    DNA
    TYPE functioning gene
    STRUCTURE 26.00 kb     8 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Map cen - C9orf12 - ECM2 - IPPK - OMD OMD - OGN - NOL8 - IARS - C9orf44 - SPTLC1 - qter
    Authors Kizawa(05)
    Physical map
    NFIL3 9q22 nuclear factor, interleukin 3 regulated ROR2 9q22.3 receptor tyrosine kinase-like orphan receptor 2 LOC347318 9q22.31 similar to 60S ribosomal protein L21 SPTLC1 9q22.1-q22.2 serine palmitoyltransferase, long chain base subunit 1 LOC389772 9 similar to Osteotesticular phosphatase; protein tyrosine phosphatase, receptor type, V LOC392368 9 similar to KIAA1553 protein LOC138652 9q22.32 similar to bA62C3.1 (similar to testicular serine protease) IARS 9q21 isoleucine-tRNA synthetase C9orf34 9q22.32 chromosome 9 open reading frame 34 OGN 9q22.3 osteoglycin (osteoinductive factor, mimecan) OMD 9p22.3 osteomodulin ASPN 9q22-q31 asporin (LRR class 1) ECM2 9q22.3 extracellular matrix protein 2, female organ and adipocyte specific C9orf12 9q21.33-q22.31 chromosome 9 open reading frame 12 BICD2 9q22.1-q22.3 chromosome 9 open reading frame 12 ANKRD19 9q22.32 ankyrin repeat domain 19 BA526D8.4 9q22.32 KRAB box containing C2H2 type zinc finger bA526D8.4 LOC389773 9 LOC389773 LOC340518 9q22.32 similar to Alox15 protein FGD3 9q22 FGD1 family, member 3 MGC26847 LOC389774 9 LOC389774 MGC11115 9q22.32 hypothetical protein MGC11115 LOC389775 9 LOC389775 NINJ1 9q22.3 ninjurin 1 PRKWNK2 9q22.3 protein kinase, lysine deficient 2 C9orf10OS 9q22.32 chromosome 9 open reading frame 10 opposite strand C9orf10 9q22.31 chromosome 9 open reading frame 10
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    8 - 2480
    EXPRESSION
    Type ubiquitous
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart    
     vesselsaorta   
    Digestiveesophagus   highly
     intestinesmall intestine  highly
    Reproductivefemale systemuterus  highly
    Respiratorylung   moderately
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Connectiveadipose  highly
    Connectivebone   
    Connectivecartilage   
    Connectivedenseligamentperidontal 
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • N terminal leucine-rich repeat and cysteine domain, playing an important role in the PLAP1/asporin
  • BMP2 interaction
  • one unique stretch of aspartic acid residues
  • HOMOLOGY
    interspecies homolog to murine Aspn
    intraspecies homolog to decorin
    Homologene
    FAMILY
  • class I SLRPs (small leucine-rich repeat proteoglycan) family
  • CATEGORY adhesion
    SUBCELLULAR LOCALIZATION extracellular
    text extracellular matrix
    basic FUNCTION
  • involved in the mineralized matrix formation in periodontal ligament
  • suppressing TGFB-mediated expression of aggrecan (ACAN) and type II collagen (COL2A1)
  • acting as a negative regulator of chondrogenesis by inhibiting TGFB function
  • negative regulator of cytodifferentiation and mineralization probably by regulating BMP-2 activity
  • blocks chondrogenesis and inhibits TGF1-induced expression of matrix genes and the resulting chondrocyte phenotypes
  • negatively regulates chondrogenesis in articular cartilage by blocking the TGF-/receptor interaction on the cell surface and inhibiting the canonical TGF-/Smad signal
  • critical regulator of TGF- in articular cartilage and thus plays an essential role in cartilage homeostasis and OA pathogenesis
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with TGFB1
  • interacting with BMP2 (inhibits BMP2-induced differentiation of periodontal ligament cells resulting from inactivation of the BMP2 signaling pathway)
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
  • to osteoarthritis in Japanese population
  • to lumbar disc degeneration (LDD)
  • Variant & Polymorphism other
  • allele D14 osteoarthritis susceptible, association of the ASPN D14 allele and knee osteoarthritis
  • allele D13 osteoarthritis protective
  • allele D14 significantly associated with LDD in Chinese and Japanese individuals
  • Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS