basic FUNCTION
| involved in the mineralized matrix formation in periodontal ligament |
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suppressing TGFB-mediated expression of aggrecan (ACAN) and type II collagen (COL2A1) |
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acting as a negative regulator of chondrogenesis by inhibiting TGFB function |
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negative regulator of cytodifferentiation and mineralization probably by regulating BMP-2 activity |
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blocks chondrogenesis and inhibits TGF1-induced expression of matrix genes and the resulting chondrocyte phenotypes |
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negatively regulates chondrogenesis in articular cartilage by blocking the TGF-/receptor interaction on the cell surface and inhibiting the canonical TGF-/Smad signal |
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critical regulator of TGF- in articular cartilage and thus plays an essential role in cartilage homeostasis and OA pathogenesis |