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FLASH GENE
Symbol ASNS contributors: - updated : 17-09-2004
HGNC name asparagine synthetase
HGNC id 753
Location 7q21.3      Physical location : 97.481.429 - 97.501.854
Synonym name
  • complementing,temperature sensitivity mutations in G1 cell cycle of BHK-21 hamster
  • glutamine-hydrolyzing
  • cell cycle control protein TS11
  • glutamine-dependent asparagine synthetase
  • Synonym symbol(s) TS11
    EC.number 6.3.5.4
    DNA
    TYPE functioning gene
    STRUCTURE 20.00 kb     14 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    regulatory sequence cytosine-phosphate-guanine/HTF
    Binding site
    text structure
  • no TATA
  • three CpG boxes
  • two nutrient responsive elements (NSRE)
  • MAPPING cloned Y linked   status confirmed
    Map cen - ABCB1 - COL1A2 - PON1 - ASNS - (EPO - GNB2 - ACHE - MUC3A ) - SERPINE1 - CUTL1 - PRKAR2B - qter
    Physical map
    SHFM1 LOC392075 7 similar to Ser/Thr protein kinase PAR-1Balpha DLX6 7q21.3 distal-less homeo box 6 DLX5 7q21.3 distal-less homeo box 5 ACN9 7q22.1 ACN9 homolog (S. cerevisiae) LOC392076 7 similar to Rpl7a protein TAC1 7q21.3-q22.1 tachykinin, precursor 1 (substance K, substance P, neurokinin 1, neurokinin 2, neuromedin L, neurokinin alpha, neuropeptide K, neuropeptide gamma) ASNS 7q21.3 asparagine synthetase LOC389534 7 LOC389534 LOC389535 7 similar to hypothetical protein LOC286031 LOC389536 7 similar to seven transmembrane helix receptor LOC389537 7 similar to olfactory receptor GA_x6K02T2PVTD-14054886-14053957 LOC389538 7 similar to hypothetical protein MGC56855 OCM 7p13-p11 oncomodulin KPI2 7q22.1 oncomodulin MIST1 7q22.1 class II bHLH protein MIST1 DKFZP434B0335 7q22.1 DKFZP434B0335 protein BRI3 7q22.1 brain protein I3 LOC55971 7q22.1 insulin receptor tyrosine kinase substrate NPTX2 7q21.3-q22.1 neuronal pentraxin II DKFZp761L1417 7q22.1 hypothetical protein DKFZp761L1417 TRRAP 7q21.3-q22.1 transformation/transcription domain-associated protein SMURF1 7q21.1-q31.1 transformation/transcription domain-associated protein LOC389539 7 similar to importin alpha 1b ARPC1A 7q22.1-q31.33 actin related protein 2/3 complex, subunit 1A, 41kDa ARPC1B 7q22.1-q31.33 actin related protein 2/3 complex, subunit 1B, 41kDa
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    - - 2348 64.4 561 - -
    - splicing 1994 64.2 561 - -
    alternative exon in the 5'utr
    - - 2345 - 561 - -
    EXPRESSION
    Type ubiquitous
    constitutive of
       expressed in (based on citations)
    organ(s)
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    glutamine aminotransferase (GATase class II) domain
    HOMOLOGY
    interspecies homolog to murine Asns
    Homologene
    FAMILY glutamine aminotransferase class 2 family
    CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    basic FUNCTION asparagine synthetase
    CELLULAR PROCESS cell cycle
    PHYSIOLOGICAL PROCESS
    text
  • asparagine biosynthesis
  • complementing the BHK cell cycle 11 mutant blocked in G1 at non permissive temperature
  • PATHWAY
    metabolism aminoacid
    signaling
    asparagine biosynthesis
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS