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FLASH GENE
Symbol ASNS contributors: - updated : 17-09-2004
HGNC name asparagine synthetase
HGNC id 753
Location 7q21.3      Physical location : 97.481.429 - 97.501.854
Synonym name
  • complementing,temperature sensitivity mutations in G1 cell cycle of BHK-21 hamster
  • glutamine-hydrolyzing
  • cell cycle control protein TS11
  • glutamine-dependent asparagine synthetase
  • Synonym symbol(s) TS11
    EC.number 6.3.5.4
    DNA
    TYPE functioning gene
    STRUCTURE 20.00 kb     14 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    regulatory sequence cytosine-phosphate-guanine/HTF
    Binding site
    text structure
  • no TATA
  • three CpG boxes
  • two nutrient responsive elements (NSRE)
  • MAPPING cloned Y linked   status confirmed
    Map cen - ABCB1 - COL1A2 - PON1 - ASNS - (EPO - GNB2 - ACHE - MUC3A ) - SERPINE1 - CUTL1 - PRKAR2B - qter
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    - - 2348 64.4 561 - -
    - splicing 1994 64.2 561 - -
    alternative exon in the 5'utr
    - - 2345 - 561 - -
    EXPRESSION
    Type ubiquitous
    constitutive of
       expressed in (based on citations)
    organ(s)
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    glutamine aminotransferase (GATase class II) domain
    HOMOLOGY
    interspecies homolog to murine Asns
    Homologene
    FAMILY glutamine aminotransferase class 2 family
    CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    basic FUNCTION asparagine synthetase
    CELLULAR PROCESS cell cycle
    PHYSIOLOGICAL PROCESS
    text
  • asparagine biosynthesis
  • complementing the BHK cell cycle 11 mutant blocked in G1 at non permissive temperature
  • PATHWAY
    metabolism aminoacid
    signaling
    asparagine biosynthesis
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS