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FLASH GENE
Symbol ASIC3 contributors: mct/npt - updated : 04-09-2015
HGNC name acid sensing (proton gated) ion channel 3
HGNC id 101
Location 7q36.1      Physical location : -
Synonym name
  • proton gated channel subunit 3
  • testis sodium channel 1
  • modulatory subunit of ASIC2a
  • proton-gated cation channel subunit
  • amiloride-sensitive cation channel 3, testis
  • Synonym symbol(s) ACCN3, TNAC1, DRASIC, SLNAC1
    DNA
    TYPE functioning gene
    STRUCTURE 4.46 kb     10 Exon(s)
    MAPPING cloned Y linked N status provisional
    Map cen - D7S2450 - RPL26 - SLC4A2 - ACCN3 - NOS3 - D7S688 - D7S2439 - D7S483 - D7S550 - qter
    Authors GeneMap (98)
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    11 - 2294 - 531 . main mRNAs expressed in both peripheral and central neuronal tissues dorsal root ganglia, spinal cord, and brain 2001 11587714
  • ASIC3A
  • 11 - 2314 - 549 - 2001 11587714
    ASIC3B
    10 - 2235 - 543 - 2001 11587714
  • ASIC3C
  • lacking exon 9 and part of exon 10
  • EXPRESSION
    Type restricted
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Endocrinethyroid    
    Nervousbraindiencephalonhypothalamusmamillary bodies  Rattus norvegicus
     braindiencephalonhypothalamussuprachiasmatic nuclei  Rattus norvegicus
     gangliasensory gangliadorsal root  
    Reproductivemale systemtestis   
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Nervousperipherous   
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Nervousneuron
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • intracellular N and C termini
  • two hydrophobic transmembrane segments (TM2)
  • a large extracellular loop including several cysteine residues with conserved spacing
  • HOMOLOGY
    Homologene
    FAMILY
  • amiloride-sensitive sodium channels superfamily
  • degenerin/epithelial sodium channel (DEG/ENaC) superfamily
  • CATEGORY transport carrier
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm
    text colocalizing with ACCN1 (ASIC2A)
    basic FUNCTION
  • proton gated cation channel subunit modulatory subunit of ACCN1 (ASIC2A)
  • involved in modulating moderate- to high-intensity pain sensation
  • may play an important role in the detection of lasting pH changes
  • might play a role in the neuronal response to noxious acidosis in sensory and central pathways
  • ligand-gated cation channel activated by extracellular protons, and is associated with an exercise-induced pressor reflex and possibly autonomic imbalance
  • ASIC3-containing neurons have a wide variety of sensory modalities in the vagal and glossopharyngeal sensory ganglia
  • may be involved in blood pressure regulation
  • thus, peripherally located ASIC1 and ASIC3 play different roles in the development of hyperalgesia after muscle inflammation
  • contribution of ASIC3 to established hypersensitivity associated with inflammation suggests that this channel may be an effective analgesic target for inflammatory pain states
  • particularly important sensor of nonadaptive pain associated with tissue acidosis
  • ASIC3A, ASIC3B, or ASIC3C are able to directly sense extracellular pH changes not only during acidification (up to pH 5.0), but also during alkalization (up to pH 8.0)
  • can thus constitute a particularly efficient molecular sensor for alkalization and/or recovery from acidification in neurons and other cell types where it may be expressed
  • is a neuronal mechanosensor for pressure-induced vasodilation that protects against pressure ulcers
  • important role of ASIC3 channels in regulating inflammatory pain via coincident detection of extracellular protons and inflammatory mediators
  • important role of ASIC3 in regulating cardiac autonomic function, whereby loss of ASIC3 alters the normal physiological response to ischemic stimuli
  • activation of ASIC3 and TRPV1 as well as enhanced SCN10A activity are essential for the development of long-lasting hyperalgesia in acid-induced, chronic, widespread muscle pain
  • fatigue reduces pH in muscle that subsequently activates ASIC3 on macrophages to enhance hyperalgesia to muscle insult
  • involved in many aspects of nociception, both in peripheral and central neurons
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • ACCN1
  • cell & other
    REGULATION
    activated by extracellular protons
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility to blood pressure regulation variation
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • Asic3(-/-) mice showed normal baseline heart rate and lower blood pressure as compared with their wild-type littermates