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FLASH GENE
Symbol ASGR2 contributors: npt/ - updated : 08-03-2006
HGNC name asialoglycoprotein receptor 2
HGNC id 743
Location 17p13.1      Physical location : 7.004.640 - 7.018.128
Synonym name
  • C-type lectin domain family 4, member H2
  • hepatic lectin H2
  • Synonym symbol(s) L-H2, ASGP-R, CLEC4H2, Hs.1259
    DNA
    TYPE functioning gene
    STRUCTURE 13.50 kb     9 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Physical map
    ALOX12P2 17p13.1 arachidonate 12-lipoxygenase pseudogene 2 ALOX12 17p13.1 arachidonate 12-lipoxygenase LOC388328 17 LOC388328 MGC49942 17p13.2 hypothetical protein MGC49942 BCL6B 17p13.1 B-cell CLL/lymphoma 6, member B (zinc finger protein) LOC201232 SLC16A11 17p13.2 solute carrier family 16 (monocarboxylic acid transporters), member 11 CLECSF13 2p13.3 likely ortholog of mouse C-type (calcium dependent, carbohydrate recognition domain) lectin, superfamily member 13 ASGR2 17p13.1 asialoglycoprotein receptor 2 ASGR1 17p12 asialoglycoprotein receptor 1 DLG4 17p13.1 discs, large (Drosophila) homolog 4 ACADVL 17p13.1 acyl-Coenzyme A dehydrogenase, very long chain DVL2 17p13.2 dishevelled, dsh homolog 2 (Drosophila) MGC2941 17p13.2 hypothetical protein MGC2941 GABARAP 17p13.1 GABA(A) receptor-associated protein DULLARD 17p13 dullard homolog (Xenopus laevis) DERP6 17p13.2 S-phase 2 protein CLDN7 17p13.1 claudin 7 SLC2A4 17p13.1 solute carrier family 2 (facilitated glucose transporter), member 4 YBX2 17p11.2-p13.1 germ cell specific Y-box binding protein EIF5A 17p13-p12 eukaryotic translation initiation factor 5A GPS2 17p13 G protein pathway suppressor 2 LOC390760 17 similar to RIKEN cDNA 2810408A11 CENTB1 17p13.2 centaurin, beta 1
    RNA
    TRANSCRIPTS type messenger
    text multiple polyadenylation sites
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    - splicing 1410 35.2 311 - Spiess
    encoding the same isoform than the variant H2'
    - splicing 1490 35.2 311 - Spiess
    encoding the same isoform than the variant 1
    - splicing 1330 - 287 - Paietta
    lacking 57 nt in exon 2 and 15 nt in exon 3 but maintaining the same reading frame than variant 1
    - splicing 1200 - 292 - Paietta
    lacking 57 nt in exon 2 but maintaining the same reading frame than variant 1
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveliver   predominantly
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Blood/Hematopoieticmonocyte Homo sapiensAdult
    Digestiveparenchymal
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a C-type lectin family domain
  • conjugated GlycoP
    HOMOLOGY
    interspecies homolog to murine Asgr2
    homolog to C.elegans B0218.6
    intraspecies homolog to ASGR1
    Homologene
    FAMILY
    CATEGORY receptor membrane
    SUBCELLULAR LOCALIZATION     plasma membrane
    text type II membrane protein
    basic FUNCTION
  • transporting these glycoproteins via a series of membrane vesicles and tubules to an acidic-sorting organelle where the receptor and ligand dissociates
  • asialoglycoprotein receptor
  • mediating galactose-terminated glycoproteins endocytosis
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS endocytosis transport
    text endocytosis of galactose-terminated glycoproteins (plasma glycoproteins)
    PATHWAY
    metabolism
    signaling signal transduction
    a component
  • functioning ligand-binding unit thought to be at least a dimer
  • INTERACTION
    DNA
    RNA
    small molecule metal binding,
  • Ca2+
  • protein
  • binding to galactose-terminated glycoproteins
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS