basic FUNCTION
| implicated in the regulation of mammalian spermatogenesis and involved in gene silencing |
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with ASF1A play a role in the efficiency of nucleosome assembly in vivo in human cells |
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role for ASF1B in the replication of human beta-cells |
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required for proliferation capacity, and is a necessary ASF1 isoform for proliferation |
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may be involved in the regulation of spermatogonial chromatin reorganization, germ-Sertoli cell interactions, and/or blood-testis barrier formation |
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importance of ASF1B expression at the time of meiotic entry, suggesting that chromatin modifications may play a central role in this process |
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is a histone H3-H4 chaperone involved in DNA replication and repair, and transcriptional regulation |
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novel role of ASF1B in human beta-cell replication and ASF1B and histone H3.3A synergistically stimulate human beta-cell proliferation |