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FLASH GENE
Symbol ASF1B contributors: mct/pgu - updated : 01-09-2010
HGNC name ASF1 anti-silencing function 1 homolog B (S. cerevisiae)
HGNC id 20996
Location 19p13.12      Physical location : 14.230.321 - 14.247.440
Synonym name
  • CCG1-interacting factor A-II
  • histone chaperone ASF1B
  • Synonym symbol(s) CIA-II, FLJ10604
    DNA
    TYPE functioning gene
    STRUCTURE 18.83 kb     4 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    regulatory sequence Promoter
    text structure
  • an E2F-responsive sequence was necessary for E2F1-induced activation of the ASF1B gene transcription.
  • MAPPING cloned Y linked N status provisional
    Physical map
    MGC10471 19p13.13 hypothetical protein MGC10471 MGC3207 19p13.13 hypothetical protein MGC3207 HSPC023 19p13.13 HSPC023 protein ZSWIM4 19p13.13 zinc finger, SWIM domain containing 4 NANOS3 19p13.13 nanos homolog 3 (Drosophila) MGC11271 19p13.13 hypothetical protein MGC11271 FLJ20241 19p13.13 putative NFkB activating protein FLJ23447 19p13.13 hypothetical protein FLJ23447 LOC90379 19p13.13 hypothetical protein BC002926 RFX1 19p13.1 regulatory factor X, 1 (influences HLA class II expression) RLN3 19p13.2 relaxin 3 (H3) WSX1 LOC342979 19p13.13 hypothetical LOC342979 LOC126037 19p13.13 similar to eukaryotic translation elongation factor 1 delta isoform 1; guanine nucleotide exchange protein LOC113230 19p13.13 hypothetical protein LOC113230 PRKACA 19p13.1 protein kinase, cAMP-dependent, catalytic, alpha ASF1B 19p13.12 ASF1 anti-silencing function 1 homolog B (S. cerevisiae) LPHN1 19p13.2 latrophilin 1 CD97 19p13.2-p13.12 CD97 antigen DDX39 19p13.13 DEAD (Asp-Glu-Ala-Asp) box polypeptide 39 PRKCL1 19p13.1-p12 protein kinase C-like 1 PTGER1 19p13.1 prostaglandin E receptor 1 (subtype EP1), 42kDa RGS19IP1 19p13.2-p13.1 regulator of G-protein signalling 19 interacting protein 1 DNAJB1 19p13.2 DnaJ (Hsp40) homolog, subfmaily B, member 1 GPSN2 19p13.12 glycoprotein, synaptic 2 NDUFB7 19p13.12-p13.11 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 7, 18kDa LOC388512 19 similar to Asialoglycoprotein receptor 2 (Hepatic lectin H2) (ASGP-R) (ASGPR) EMR3 19p13.1 egf-like module containing, mucin-like, hormone receptor-like 3 ZNF333 19p13 zinc finger protein 333 EMR2 19p13.1 egf-like module containing, mucin-like, hormone receptor-like sequence 2 OR7C1 19p13.1 olfactory receptor, family 7, subfamily C, member 1 OR7A5 19p13.1 olfactory receptor, family 7, subfamily A, member 5 pseudogene
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    4 - 1746 - 202 - 2009 20016786
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Lymphoid/Immunetonsils   highly
    Reproductivefemale systemuteruscervix highly
     male systemtestis  highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    interspecies ortholog to murine Asf1b
    Homologene
    FAMILY
  • ASF1-like family
  • CATEGORY chaperone/stress
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,chromatin/chromosome
    basic FUNCTION
  • implicated in the regulation of mammalian spermatogenesis and involved in gene silencing
  • with ASF1A play a role in the efficiency of nucleosome assembly in vivo in human cells
  • required for proliferation capacity, and is a necessary ASF1 isoform for proliferation
  • CELLULAR PROCESS nucleotide, transcription
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • histone H3
  • bromodomains of TFIID
  • physiological substrates of TLK1, TLK2 (with ASF1A, are phosphorylated by Tlks)
  • direct transcriptional target of transcription factor E2F1
  • cell & other
    REGULATION
    activated by ASF1A and ASF1B are upregulated followed by cell proliferation signal, but ASF1B is uniquely regulated by transcription factors E2F during cell cycle progression
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS