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FLASH GENE
Symbol ASF1B contributors: mct/pgu - updated : 27-04-2020
HGNC name ASF1 anti-silencing function 1 homolog B (S. cerevisiae)
HGNC id 20996
Location 19p13.12      Physical location : 14.230.321 - 14.247.440
Synonym name
  • CCG1-interacting factor A-II
  • histone chaperone ASF1B
  • Synonym symbol(s) CIA-II, FLJ10604
    DNA
    TYPE functioning gene
    STRUCTURE 18.83 kb     4 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    regulatory sequence Promoter
    text structure
  • an E2F-responsive sequence was necessary for E2F1-induced activation of the ASF1B gene transcription.
  • MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    4 - 1746 - 202 - 2009 20016786
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Lymphoid/Immunetonsils   highly
    Reproductivefemale systemuteruscervix highly
     male systemtestis  highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    interspecies ortholog to murine Asf1b
    Homologene
    FAMILY
  • ASF1-like family
  • CATEGORY chaperone/stress
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,nucleoplasm
    intracellular,nucleus,chromatin/chromosome
    basic FUNCTION
  • implicated in the regulation of mammalian spermatogenesis and involved in gene silencing
  • with ASF1A play a role in the efficiency of nucleosome assembly in vivo in human cells
  • role for ASF1B in the replication of human beta-cells
  • required for proliferation capacity, and is a necessary ASF1 isoform for proliferation
  • may be involved in the regulation of spermatogonial chromatin reorganization, germ-Sertoli cell interactions, and/or blood-testis barrier formation
  • importance of ASF1B expression at the time of meiotic entry, suggesting that chromatin modifications may play a central role in this process
  • is a histone H3-H4 chaperone involved in DNA replication and repair, and transcriptional regulation
  • novel role of ASF1B in human beta-cell replication and ASF1B and histone H3.3A synergistically stimulate human beta-cell proliferation
  • CELLULAR PROCESS nucleotide, transcription
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • histone H3
  • bromodomains of TFIID
  • physiological substrates of TLK1, TLK2 (with ASF1A, are phosphorylated by Tlks)
  • direct transcriptional target of transcription factor E2F1
  • histone H3.3 is required for ASF1B ability to regulate proliferation
  • incretin signaling regulates the abundance and functional activity of ASF1B
  • cell & other
    REGULATION
    activated by ASF1A and ASF1B are upregulated followed by cell proliferation signal, but ASF1B is uniquely regulated by transcription factors E2F during cell cycle progression
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    promotes cell proliferation and migration via activation of the AKT1 pathway in clear cell renal cell carcinoma
    constitutional     --over  
    is sufficient to induce human beta-cell proliferation
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • viability of Asf1b-null mice suggests that Asf1b is dispensable for mouse development, but these mice showed reduced reproductive capacity compared with wild-type controls