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FLASH GENE
Symbol ASF1A contributors: mct - updated : 11-10-2017
HGNC name ASF1 anti-silencing function 1 homolog A (S. cerevisiae)
HGNC id 20995
Location 6q22.31      Physical location : 119.215.240 - 119.230.333
Synonym name
  • anti-silencing function 1A
  • anti-silencing factor 1 homolog
  • CCG1-interacting factor A
  • histone chaperone ASF1A
  • cell cycle gene 1 -interacting factor A or antisilencing function 1
  • Synonym symbol(s) ASF1P, RP3-329L24.1, CIA, DKFZP547E2110, HSPC146, CGI-98
    DNA
    TYPE functioning gene
    STRUCTURE 15.10 kb     4 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    4 - 2525 - 204 - Sillje (2001)
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveesophagus   highly
    Endocrineneuroendocrinepituitary  highly
    Hearing/Equilibriumear   highly
    Lymphoid/Immunelymph node   highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    Homologene
    FAMILY
  • ASF1 family
  • CATEGORY chaperone/stress
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus
    basic FUNCTION
  • involved in chromatin binding
  • required for histone H3 lysine 56 acetylation, a modification associated with S phase in mitosis and meiosis
  • involved in chromosome condensation depending on the ability of ASF1A to physically interact with its deposition substrate, histone H3, in addition to its cochaperone, HIRA
  • with ASF1B play a role in the efficiency of nucleosome assembly in vivo in human cells (Galvani 2008)
  • Histone H3/H4 chaperone, target for cell-cycle regulated Tousled-like kinases (TLKs) and both proteins cooperate during chromatin replication (Pilyugin 2009)
  • highly conserved histone H3/H4 chaperone that synergizes with two other histone chaperones, CHAF1A and HIRA, in DNA synthesis-coupled and DNA synthesis-independent nucleosome assembly
  • HIRA and ASF1A, play an important role in muscle differentiation by facilitating MYOD1 expression
  • one of its critical biological functions involves activity in the transcription initiation step (Akai 2010)
  • is a histone chaperone that participates in chromatin higher-order organization and is required for appropriate chromatin assembly
  • depletion of ASF1A produces a recovery defect, and both TLK2 and ASF1A are required to restore histone H3 incorporation into damaged chromatin
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component part of the quaternary HIRA/UBN1/CABIN1/ASF1A (HUCA) complex, assembled from recombinant proteins
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • physiological substrates of TLK1, TLK2 (wth ASF1B, are phosphorylated by Tlks) (Sillje 2001)
  • cooperated with HIRA and was indispensable for MEF2A-dependent transcription
  • interplay between UBE2A, UBE2B and ASF1A associates with tumorigenesis
  • TLK2 promotes ASF1A function during the DNA damage response in G2 to allow for proper restoration of chromatin structure at the break site and subsequent recovery from the arrest
  • TLK1 and TLK2, regulate ASF1A, a histone H3/H4 chaperone, and likely other substrates, and their activity has been implicated in transcription, DNA replication, DNA repair
  • cell & other
    REGULATION
    activated by ASF1A and ASF1B are upregulated followed by cell proliferation signal, but ASF1B is uniquely regulated by transcription factors E2F during cell cycle progression (Hayashi 2007)
    Other post-translational regulation of ASF1A by TLK kinases (Pilyugin 2009)
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS