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FLASH GENE
Symbol ASCL3 contributors: mct/npt - updated : 19/09/2008
HGNC name achaete-scute complex homolog 3 (Drosophila)
HGNC id 740
Location 11p15.3      Physical location : 8.959.118 - 8.964.580
Synonym name
  • achaete-scute complex (Drosophila) homolog-like 3
  • bHLH transcriptional regulator Sgn-1
  • bHLH transcription factor Sgn-1 (Salivary Glands 1)
  • Synonym symbol(s) SGN1, HASH3, bHLHa42
    DNA
    TYPE functioning gene
    STRUCTURE 5.46 kb     2 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    2 - 650 - 181 - Jonsson (2004)
    EXPRESSION
    Type restricted
       expressed in (based on citations)
    organ(s)
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Connective    
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • helix-loop-helix (HLH) motif
  • mono polymer dimer
    HOMOLOGY
    interspecies homolog to murine Ascl3
    homolog to C.elegans k11d2.2
    intraspecies homolog to ASCL4
    Homologene
    FAMILY
  • basic helix-loop-helix (BHLH) family of transcription factors
  • ASC subfamily
  • CATEGORY regulatory , transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • inhibiting myogenesis
  • playing an essential role for the determination of cell fate and the development and differentiation of numerous tissues
  • implicated in cell fate specification and differentiation
  • CELLULAR PROCESS nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS detoxification
    text transcriptional repressor
    PATHWAY
    metabolism
    signaling
    a component
  • dimerization with another bHLH protein (required for efficient DNA binding)
  • INTERACTION
    DNA binding
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS