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FLASH GENE
Symbol ASB2 contributors: npt/ - updated : 04-09-2008
HGNC name ankyrin repeat and SOCS box-containing 2
HGNC id 16012
Location 14q31-q32      Physical location : 94.400.512 - 94.423.767
Synonym name ankyrin repeat-containing protein ASB-2
Synonym symbol(s) ASB-2, MGC40044
DNA
TYPE functioning gene
STRUCTURE 23.25 kb     8 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
Physical map
RPL36AP4 14 ribosomal protein L36a pseudogene 4 COX8-3 14q32.13 cytochrome c oxidase subunit VIII isoform 3 KIAA1409 14q32.13 KIAA1409 PRIMA1 14q32.13 proline rich membrane anchor 1 LOC388006 14 LOC388006 C14orf86 14 chromosome 14 open reading frame 86 LOC90050 14q32.13 hypothetical protein BC009073 ASB2 14q31-q32 ankyrin repeat and SOCS box-containing 2 C14orf48 14q32.13 chromosome 14 open reading frame 48 C14orf137 14q32.13-q32.2 chromosome 14 open reading frame 137 DDX24 14q32 DEAD (Asp-Glu-Ala-Asp) box polypeptide 24 FAM14B 14q32.13 family with sequence similarity 14, member B IFI27 14q32 interferon, alpha-inducible protein 27 FAM14A 14q32.13 family with sequence similarity 14, member A KIAA1622 14q32.2 KIAA1622 SERPINA10 14q32.13 serine (or cysteine) proteinase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 10 SERPINA6 14q32.1 serine (or cysteine) proteinase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 6 LOC390502 14 similar to Alpha-1-antitrypsin-related protein precursor SERPINA1 14q32.1 serine (or cysteine) proteinase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 LOC256394 14q32.2 similar to serine (or cysteine) proteinase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 4; protease inhibitor 4 (kallistatin)
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
8 - 2742 64.9 587 - -
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
blood / hematopoieticspleen    
Cardiovascularheart    
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Lymphoid    
Muscularstriatumskeletal  
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • fifteen N terminal ankyrin (ANK) repeats
  • a conserved C-terminal SOCS box motif
    • HOMOLOGY
    interspecies ortholog to murine Asb2
    homolog to murine Asb2
    Homologene
    FAMILY
  • ankyrin repeat and SOCS box-containing (ASB) family of proteins
    • CATEGORY regulatory , signaling
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    basic FUNCTION
  • inhibits cytokine signaling
    • CELLULAR PROCESS protein, post translation
    protein, degradation
    protein, ubiquitin dependent proteolysis
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
    intracellular signaling cascade
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • JAK kinases
  • activated cytokine receptors
  • elonguin B/C complex
    • cell & other
    REGULATION
    induced by cytokines
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS