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FLASH GENE
Symbol ASB11 contributors: mct - updated : 10-06-2020
HGNC name ankyrin repeat and SOCS box-containing 11
HGNC id 17186
Location Xp22.2      Physical location : 15.301.626 - 15.333.727
Synonym name
  • ankyrin repeat domain-containing SOCS box protein ASB11
  • ankyrin repeat and SOCS box-containing protein 11, isoform a
  • Synonym symbol(s) DKFZp779E2460, MGC119168, MGC119169
    DNA
    TYPE functioning gene
    STRUCTURE 33.94 kb     7 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    7 - 2815 - 323 - 2019 31387940
    7 - 2790 32 302 - 2019 31387940
    7 - 2764 - 306 - 2019 31387940
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Muscular    
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • six ankyrin repeats
  • one SOCS box domain
  • HOMOLOGY
    interspecies ortholog to murine Asb11 (85 pc)
    Homologene
    FAMILY
  • ankyrin repeat
  • SOCS box-containing (ASB) family
  • CATEGORY regulatory , signaling
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    intracellular,cytoplasm,cytosolic
    basic FUNCTION
  • involved in couplage of suppressor of cytokine signaling (SOCS) protein and their partners with elongin B and C
  • is likely a principal regulator of embryonic as well as adult regenerative myogenesis
  • ASB11 is a novel endoplasmic reticulum-associated ubiquitin ligase with the ability to interact and promote the ubiquitination of RPN1, an integral protein of the oligosaccharyltransferase (OST) glycosylation complex
  • CELLULAR PROCESS protein, post translation, targeting
    protein, ubiquitin dependent proteolysis
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
    intracellular signaling cascade
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • JAK kinases
  • activated cytokine receptors
  • elonguin B/C complex
  • expression of ASB11 can increase RPN1 protein turnover (24337577)
  • CUL5-ASB11 is the E3 ligase targeting BIK for ubiquitination and degradation
  • different cellular stresses regulate BIK ubiquitination by ASB11 in opposing directions, which determines whether or not cells survive
  • cell & other
    REGULATION
    induced by cytokines
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS