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FLASH GENE
Symbol ASB10 contributors: mct - updated : 09-05-2018
HGNC name ankyrin repeat and SOCS box-containing 10
HGNC id 17185
Corresponding disease
GLC1F glaucoma, primary open angle 1F
Location 7q36.1      Physical location : 150.872.784 - 150.884.919
Synonym symbol(s) GLC1F
DNA
TYPE functioning gene
STRUCTURE 12.13 kb     5 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
text multiple alternatively spliced transcripts
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
5 - 1820 46.5 429 - 2013 23901248
6 - 1738 - 452 - 2013 23901248
6 - 1934 - 467 - 2013 23901248
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Visualeyeanterior segment    Homo sapiens
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • seven N terminal ANK repeats
  • one C terminal SOCS box domain
  • HOMOLOGY
    interspecies homolog to murine Asb10
    homolog to Drosophila lk6
    homolog to C.elegans r166.5
    Homologene
    FAMILY
  • ankyrin repeat and SOCS box containing (ASB) family of proteins
  • CATEGORY regulatory , signaling
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus
    text
  • localized in intracellular structures in human trabecular meshwork (HTM) cells
  • basic FUNCTION
  • may play a role in ubiquitin-mediated degradation pathways in trabecular meshwork (TM) cells
  • CELLULAR PROCESS protein, post translation, targeting
    protein, degradation
    protein, ubiquitin dependent proteolysis
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
    intracellular signaling cascade
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • JAK kinases
  • activated cytokine receptors
  • cell & other
    REGULATION
    induced by cytokines
    ASSOCIATED DISORDERS
    corresponding disease(s) GLC1F
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS