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FLASH GENE
Symbol ASAP2 contributors: mct/npt - updated : 29-06-2009
HGNC name ArfGAP with SH3 domain, ankyrin repeat and PH domain 2
HGNC id 2721
Location 2p25.1      Physical location : 9.346.893 - 9.545.812
Synonym name
  • PYK C terminus associated protein
  • development and differentiation enhancing factor 2
  • paxillin-associated protein with ARFGAP activity 3
  • centaurin, beta 3
  • Synonym symbol(s) KIAA0400, PAP, PAG3, SHAG1, AMAP2, FLJ42910, DDEF2, CENTB3
    DNA
    TYPE functioning gene
    STRUCTURE 198.91 kb     28 Exon(s)
    MAPPING cloned Y linked N status confirmed
    Map pter - D2S359 - ASAP2 - ODC1 - D2S287 - cen
    Authors Gene Map (98)
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    28 - 5589 107 961 - Andreev (1999)
    28 - 5724 111.5 1006 - Andreev (1999)
    EXPRESSION
    Type widely
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart    
    Digestivemouth   highly
     stomach   highly
    Endocrinepancreas    
    Nervousbrain    
    Respiratoryrespiratory tractlarynx  highly
    Urinarykidney    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Epithelialsecretoryglandularendocrine 
    Epithelialsecretoryglandularexocrine 
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period pregnancy
    Text placenta
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • from the N terminus, a pleckstrin homology domain PH
  • a GAP domain that includes a zinc finger motif
  • three ankyrin repeats
  • a proline-rich region with alternative splicing and SH3 binding domains
  • eight repeats of the sequence E/DLPPKP and a C terminal SH3 domain, binding SAMP motif of APC specifically (Matsui 2008)
  • HOMOLOGY
    Homologene
    FAMILY
  • beta family
  • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,Golgi
    text localizing to focal adhesions
    basic FUNCTION
  • ADP ribosylation factor (ARF) GTPase activating protein,phosphatidyl 4,5 biphosphate (PIP2)-dependent
  • regulator and coordinator of cell growth, actin cytoskeletal organization and ARF nucleotide cycle
  • cycling with FA proteins when cells are stimulated to move
  • enzyme activator
  • present in cell structures required for cell migration and invasion, such as focal adhesions, invadopodias, and podosomes, and are involved in endocytosis and cytoskeletal remodeling (Ismail 2010)
  • involvement in carcinogenesis and metastasis highlights the importance of the presented structure in general and the Ca2+-binding pocket in particular as it may give clues for designing inhibitors for therapeutic applications (Ismail 2010)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS development
    PATHWAY
    metabolism
    signaling
    a component
  • associated with and phosphorylated by SRC
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • GTPase activating protein for ARF1, ARF6
  • DDEF1 (ASAP1)
  • binds to SH3KBP1 and CBL, but undergoes mostly polyubiquitination
  • cell & other
  • inhibiting the formation of PDGF-induced dorsal membrane ruffles in NIH 3T3 fibroblasts, when overexpressed
  • REGULATION
    Other phosphorylated by SRC
    targeted by PYK2
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS