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FLASH GENE
Symbol ARTN contributors: - updated : 06-01-2007
HGNC name artemin
HGNC id 727
Location 1p32-p31.3      Physical location : 44.398.991 - 44.402.911
Synonym name
  • enovin
  • neublastin
  • Synonym symbol(s) EVN, NBN
    DNA
    TYPE functioning gene
    STRUCTURE 3.00 kb     3 Exon(s)
    Genomic sequence alignment details
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Physical map
    EBNA1BP2 1p35-p33 EBNA1 binding protein 2 FLJ32000 1p34.1 hypothetical protein FLJ32000 LOC256339 1p34.1 similar to ENSANGP00000010412 MGC17299 1p34.1 hypothetical protein MGC17299 MGC52423 1p34.1 hypothetical protein MGC52423 TIE 1p34 tyrosine kinase with immunoglobulin and epidermal growth factor homology domains CDC20 9q13-q21 CDC20 cell division cycle 20 homolog (S. cerevisiae) MPL 1p34 myeloproliferative leukemia virus oncogene ELOVL1 1p34.1 elongation of very long chain fatty acids (FEN1/Elo2, SUR4/Elo3, yeast)-like 1 MED8 1p34.1 mediator of RNA polymerase II transcription, subunit 8 homolog (yeast) LOC388625 1 similar to FLJ00408 protein HT036 1p34.1 hypothetical protein HT036 PTPRF 1p34 protein tyrosine phosphatase, receptor type, F JMJD2 1p34.1 jumonji domain containing 2 SIAT6 1p34.1 sialyltransferase 6 (N-acetyllacosaminide alpha 2,3-sialyltransferase) ARTN 1p32-p31.3 artemin IPO13 1p34.1 importin 13 DPH2L2 1p34 diptheria toxin resistance protein required for diphthamide biosynthesis-like 2 (S. cerevisiae) ATP6V0B 1p32.3 ATPase, H+ transporting, lysosomal 21kDa, V0 subunit c'' B4GALT2 1p34-p33 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 2 MGC45441 1p34.1 hypothetical protein MGC45441 SLC6A9 1p33 solute carrier family 6 (neurotransmitter transporter, glycine), member 9 LOC391034 1 similar to keratin 8; cytokeratin 8; keratin, type II cytoskeletal 8 FLJ40160 1p34.1 hypothetical protein FLJ40160 LOC128208 1p34.1 similar to dJ675G8.1 (novel zinc finger protein) DMAP1 1p34 DNA methyltransferase 1 associated protein 1 PRNPIP 1p32 prion protein interacting protein FLJ10597 1p34.1 hypothetical protein FLJ10597 FLJ22353 1p34.1 hypothetical protein FLJ22353 LOC339541 1p34.1 hypothetical LOC339541 LOC256686 1p34.1 hypothetical LOC256686 KIF2C 1p32.2 kinesin family member 2C RPS8 1p32.2-p32.1 ribosomal protein S8 LOC391035 1 similar to 40S ribosomal protein S15a VMD2L2 1p33-p32.3 Homo sapiens vitelliform macular dystrophy 2-like protein 2 (VMD2L2), mRNA. CNK 1p34.1 cytokine-inducible kinase LOC343521 1p34.1 similar to hypothetical protein 4833401D15 LOC388626 1 LOC388626
    RNA
    TRANSCRIPTS type messenger
    text two of the four encode the same protein (variant 1 and 2)
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    - splicing 1410 22.9 220 - Masure
  • having an alternate 5' UTR
  • encoding the same isoform than variant 2
  • - splicing 1162 22.9 220 - Masure
  • having an alternate 5'UTR
  • encoding the same isoform than variant 1
  • - splicing 1892 24.5 220 - Masure
  • having a different 5' end sequence
  • encoding an isoform with a unique amino terminus
  • - splicing 1160 - 237 - Masure,Rosenblad
    encodes an isoform with a unique amino terminus.
    EXPRESSION
    Type restricted
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveesophagus    
     stomach    
    Endocrineparathyroid    
    Reproductivemale systemprostate   
    Respiratoryrespiratory tractlarynx   
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Muscularsmoothvessel  
    Nervousperipherous   
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period fetal, pregnancy
    Text placenta, lung, kidney
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    conjugated GlycoP
    mono polymer homomer , dimer
    HOMOLOGY
    interspecies homolog to murine Artn
    intraspecies homolog to artemin
    Homologene
    FAMILY
  • glial cell-lines derived neutrophic factor family of ligand (GDNF)
  • TGF-beta superfamily
  • CATEGORY regulatory , signaling growth factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • neutrophic factor involved in stimulation of neurite outgrowth, exerting selective effects on pain sensation
  • ligand for the RET receptor and using GFR-alpha 3 as coreceptor
  • activating the GFR alpha 1 RET receptor complex
  • acting as a guidance factor that encourages sympathetic fibers to follow blood vessels as they project toward their final target tissues
  • promoting the survival of ventral midbrain dopaminergic neurons in culture and prevents their degeneration after treatment by 6 hydroxydopamine in vivo
  • exhibiting neurotrophic activity on mesencephalic dopaminergic and motor neurons
  • involved in processes subserving both the organization of the cortical region during development and the functional activity and maintenance of the mature hippocampal neurons
  • CELLULAR PROCESS cell life, proliferation/growth
    PHYSIOLOGICAL PROCESS development
    text
  • neuroblast proliferation
  • neuronal development
  • PATHWAY
    metabolism
    signaling signal transduction
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • ligand for GFRA3
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS