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FLASH GENE
Symbol ART4 contributors: - updated : 10-11-2006
HGNC name ADP-ribosyltransferase 4 (Dombrock blood group)
HGNC id 726
Corresponding disease
DO Dombrock blood group
Location 12q13.2-q13.3      Physical location : 14.982.244 - 14.996.413
Synonym name
  • ADP-ribosyltransferase 4
  • Dombrock blood group
  • CD297 antigen
    • Synonym symbol(s) DOK1, CD297
    EC.number 2.4.2.31
    DNA
    TYPE functioning gene
    STRUCTURE 14.00 kb     3 Exon(s)    1 Copie(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    text two alternate isoforms
    EXPRESSION
    Type
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart    
     vessel   highly
    Lymphoid/Immunespleen   highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / hematopoieticbone marrow   
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Blood/Hematopoieticmonocyte
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    conjugated GlycoP
    HOMOLOGY
    interspecies ortholog to murine Art4
    ortholog to chimpanzee art4
    Homologene
    FAMILY Arg-specific ADP-ribosyltransferase family
    CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     plasma membrane
    text attached to the membrane by a GPI-anchor
    basic FUNCTION
  • acting as blood group antigen
  • involved in the transfer of the ADP-ribose moiety from NAD+ to a specific amino acid in the target protein
    • CELLULAR PROCESS protein, post translation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule cofactor, nucleotide,
    NAD+
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) DO
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS