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FLASH GENE
Symbol ARRB2 contributors: mct - updated : 13-04-2010
HGNC name arrestin, beta 2
HGNC id 712
Location 17p13.2      Physical location : 4.613.788 - 4.624.794
Synonym name arrestin 3
Synonym symbol(s) ARB2, ARR2, BARR2, DKFZp686L0365
DNA
TYPE functioning gene
STRUCTURE 11.01 kb     15 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
Physical map
MGC29671 17p13.3 hypothetical protein MGC29671 LOC124976 17p13.3 hypothetical protein LOC124976 MYBBP1A 17p13.3 MYB binding protein (P160) 1a FLJ90165 17p13.3 hypothetical protein FLJ90165 LOC124974 17p13.3 thioredoxin 1 pseudogene 4 FLJ42461 17p13.3 FLJ42461 protein ALOX15 17p13.1 arachidonate 15-lipoxygenase PELP1 17p13.3 arachidonate 15-lipoxygenase LOC390758 17 similar to 40S RIBOSOMAL PROTEIN S12 ARRB2 17p13 arrestin, beta 2 CXCL16 17p13 chemokine (C-X-C motif) ligand 16 LOC388322 17 similar to HSPC296 ZMYND15 17p13.3 zinc finger, MYND domain containing 15 TM4SF5 17p13.3 transmembrane 4 superfamily member 5 LOC284013 17p13.3 secretory protein LOC284013 LOC388323 17 similar to RIKEN cDNA C730027E14 PSMB6 17p13 proteasome (prosome, macropain) subunit, beta type, 6 PLD2 17p13.1 phospholipase D2 LOC284015 17p13.3 similar to Vacuolar ATP synthase 16 kDa proteolipid subunit MINK 17p13 similar to Vacuolar ATP synthase 16 kDa proteolipid subunit CHRNE 17p13.1 cholinergic receptor, nicotinic, epsilon polypeptide GP1BA 17pter-p12 glycoprotein Ib (platelet), alpha polypeptide SLC25A11 17p13.3 solute carrier family 25 (mitochondrial carrier; oxoglutarate carrier), member 11 DKFZP566H073 17p13.3 DKFZP566H073 protein PFN1 17p13.3 profilin 1 ENO3 17pter-p12 enolase 3, (beta, muscle) SPAG7 17p13.2 sperm associated antigen 7 CAMTA2 17p13.3 calmodulin binding transcription activator 2 LOC388324 17 LOC388324 KIF1C 17p13 kinesin family member 1C FLJ10060 17p13.3 putative G-protein coupled receptor GPCR42 FLJ30726 17p13.3 hypothetical protein FLJ30726
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
14 - 1936 46 409 - 1993 8486659
14 - 1891 - 394 - 1993 8486659
EXPRESSION
Type ubiquitous
   expressed in (based on citations)
organ(s)
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • N-terminal receptor activation-recognition domain
  • a binding site for the common PDE4D catalytic unit
  • two regions in the beta-arrestin 2 C-domain that confer specificity for PDE4D5 binding
  • C-terminal secondary receptor-binding domain
  • HOMOLOGY
    intraspecies homolog to alpha transducin
    Homologene
    FAMILY
  • arrestin family
  • CATEGORY adaptor , regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic,vesicle
    intracellular,nucleus
    text
  • predominant cytoplasmic distribution at steady state
  • basic FUNCTION
  • Ca2+ binding protein of the retinal rd outer segments, binding to P-rhodopsin
  • inhibiting further G protein activation of desensitized receptor-arrestin complex and sequestering it through clathrin coated pits
  • also regulator of beta-adrenergic receptor A, enhancing beta2AR receptor mediated nuclear translocation of ERK
  • specialized adaptor/scaffolding protein required for internalization and signaling of members of the G protein-coupled receptor superfamily
  • having a broad role in the trafficking of integral plasma membrane protein
  • beta-arrestin-mediated signaling regulates protein synthesis
  • involved in synaptic transmission in photoreceptor cells
  • having a role as a positive regulator in NFKB signaling pathway by connecting CARD10 to GPCRs
  • key role in mediating cellular cytoprotective functions by a 7-transmembrane receptor and define the biochemical pathways involved
  • acts as a corepressor of androgen receptor (AR) by serving as a scaffold for MDM2 leading to the AR ubiquitylation and degradation
  • is required for complement C1QA expression in macrophages and constrains factor-independent survival
  • both ARRB1 and ARRB2 play a novel and shared role in inhibiting G protein-dependent ERK1/2 phosphorylation
  • ARRB1, ARRB2 are cytosolic proteins well-known to participate in G protein-coupled receptor desensitisation and signalling
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • part of AIP4
  • arrestin-2 complex that functions on endosomes to regulate sorting of CXCR4 into the degradative pathway
  • its subcellular localization and function is tightly regulated by MDM2 E3 ligase activity
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • endosomal sorting molecule together with AIP4 to mediate CXCR4 entry into a degradative pathway
  • interaction with SLC9A5 (sequences within the N-terminal receptor activation-recognition domain and the C-terminal secondary receptor-binding domain of ARRB2 conferred strong binding to the C terminus of SLC9A5)
  • associated with CARD10, a scaffold protein that plays an essential role in GPCR-induced NFKB activation, suggesting that it may recruit CARD10 to Lysophosphatidic acid receptors
  • binding between a distal C-terminus fragment of cannabinoid receptor 1 (CNR1) and arrestin-2 (ARRB2)
  • ARRB2-RAF1 interaction is enhanced by receptor binding
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS