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FLASH GENE
Symbol ARRB1 contributors: mct - updated : 18-12-2013
HGNC name arrestin, beta 1
HGNC id 711
Location 11q13.4      Physical location : 74.976.481 - 75.062.873
Synonym name arrestin 2
Synonym symbol(s) ARR1, ARB1
DNA
TYPE functioning gene
STRUCTURE 86.39 kb     16 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
Physical map
PLEKHB1 11q13.5-q14.1 pleckstrin homology domain containing, family B (evectins) member 1 RAB6A 2q14-q21 RAB6A, member RAS oncogene family LOC268276 11q13 musashi 1 pseudogene MRPL48 11q13.2 mitochondrial ribosomal protein L48 E2IG2 11q13.3 E2IG2 protein FLJ11848 11q13.3 hypothetical protein FLJ11848 TSARG6 11q13.3 testis spermatogenesis apoptosis-related protein 6 UCP2 11q13 uncoupling protein 2 (mitochondrial, proton carrier) UCP3 11q13 uncoupling protein 3 (mitochondrial, proton carrier) DKFZP586P0123 11q13.3 DKFZP586P0123 protein PME-1 11q13.3 protein phosphatase methylesterase-1 LOC283208 FLJ32029 KCNE3 11q13-q14 potassium voltage-gated channel, Isk-related family, member 3 HCP27 11q13.3 cytochrome c, somatic pseudogene LOC387787 11 similar to RIKEN cDNA 2610209A20 POLD3 11q14 similar to RIKEN cDNA 2610209A20 BNF1 FLJ22596 11q13.3 hypothetical protein FLJ22596 LOC387788 11 similar to ribosomal protein S12 KIAA1991 11q13.3 hypothetical protein KIAA1991 KIAA0102 11q13.3 hypothetical protein KIAA1991 LOC387789 11 LOC387789 NEU3 11q13.5 sialidase 3 (membrane sialidase) LOC390224 11 similar to olfactory receptor MOR101-2 LOC341152 11q13.3 similar to olfactory receptor MOR101-1 LOC390225 11 similar to olfactory receptor MOR101-2 SLCO2B1 11q13 solute carrier organic anion transporter family, member 2B1 ARRB1 11q13 arrestin, beta 1 RPS3 11q13.3-q13.5 ribosomal protein S3 FLJ33790 11q13.3 hypothetical protein FLJ33790 PP1665 11q13.3 hypothetical protein PP1665 SERPINH1 11q13.5 serine (or cysteine) proteinase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1) MAP6 6p12-p11 microtubule-associated protein 6 MGAT2 14q21 mannosyl (alpha-1,6-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferase DGAT2 11q13.3 diacylglycerol O-acyltransferase homolog 2 (mouse) UVRAG 11q13 UV radiation resistance associated gene WNT11 11q13.5 wingless-type MMTV integration site family, member 11 PRKRIR 11q13.5 protein-kinase, interferon-inducible double stranded RNA dependent inhibitor, repressor of (P58 repressor) LOC387790 11 LOC387790 C11orf30 11q13.5 chromosome 11 open reading frame 30 GARP 11q13.5-q14 glycoprotein A repetitions predominant LOC390226 11 similar to Olfactory guanylyl cyclase GC-D precursor (Guanylate cyclase, olfactory) E2IG4 11q13.3 hypothetical protein, estradiol-induced PHCA 11q13.4 phytoceramidase, alkaline IMAGE:4907098 11q13.4 beta-1,3-N-acetylglucosaminyltransferase protein
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
16 - 2204 47.1 418 - 2005 16181421
15 splicing 2180 46.1 410 - 2005 16181421
lacking an alternate in-frame exon compared to variant 1
EXPRESSION
Type ubiquitous
   expressed in (based on citations)
organ(s)
cells
SystemCellPubmedSpeciesStageRna symbol
Visualrod photoreceptor
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period pregnancy
Text placenta
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • N- terminus of ARRB1 (AAs 1186) is critical for binding to TP53
  • arrestin C terminal domain
  • mono polymer heteromer , trimer
    HOMOLOGY
    interspecies homolog to murine Sag
    intraspecies homolog to alpha transducin,to ARRB2
    homolog to arrb2
    Homologene
    FAMILY
  • arrestin family
  • CATEGORY regulatory , signaling neurotransmitter
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,Golgi
    intracellular,cytoplasm,organelle,lysosome
    intracellular,cytoplasm,cytosolic,granule
    intracellular,nucleus,chromatin/chromosome
    text
  • nuclear translocation induced by the stimulation of delta-opioid receptor, a member of the GPCR family
  • cytosolic ARRB1 mediates catecholamine-induced activation of AKT and MDM2, whereas nuclear ARRB1 serves as an adaptor for MDM2-dependent ubiquitination of TP53
  • mediates signaling within the nucleus
  • basic FUNCTION
  • agonist induced phosphorylation dependent G protein coupled receptors internalisation and desentisation
  • Ca2+ binding protein of the retinal rod outer segments, binding to P-rhodopsin
  • inhibiting further G protein activation desensitized receptor-arrestin complex and sequestered through clathrin coated pits
  • also regulator of beta-adrenergic receptor A and activator of the lymphoid enhancer factor (LEF) transcription factor
  • involved in synaptic transmission in photoreceptor cells
  • playing a crucial role for ubiquitination and down-regulation of the insulin-like growth factor-1 receptor by acting as adaptor for the MDM2 E3 ligase
  • facilitating the recruitment of histone acetyltransferase p300 by selective enrichment at specific promoters such as that of p27 and c-fos
  • having a broad role in the trafficking of integral plasma membrane protein
  • beta-arrestin-mediated signaling regulates protein synthesis
  • required for the maintenance of a ADRB1-EGFR interaction that can direct cytosolic targeting of ERK in response to catecholamine stimulation
  • both ARRB1 and ARRB2 play a novel and shared role in inhibiting G protein-dependent ERK1/2 phosphorylation
  • emerging role of ARRB1 as an E3-ligase adaptor in the nucleus
  • critical role for ARRB1 nuclear localization in scaffolding and transcriptional regulation
  • ARRB1, ARRB2 are cytosolic proteins well-known to participate in G protein-coupled receptor desensitisation and signalling
  • role in promoting thrombus formation, in part through its participation in ITGA2/ITGB3 signalling
  • CELLULAR PROCESS nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling neurotransmission , signal transduction
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • DVLZ, DVL1 (enhanced by phosphorylation)
  • required with G protein (alphaq/11) for full activation of RhoA and subsequent formation of stress fibers
  • novel functions of ARRB1 in binding to the GNB1/GNG2 subunits of heterotrimeric G-proteins and promoting GNB-mediated Akt signalling GNB1/GNG2 for NF-kappaB activation
  • binding to MAP2K1, influencing the phosphorylation and the internalization of ARRB1
  • interacts with ESCRT-0, a protein complex that recognizes and sorts ubiquitinated cargo into the degradative pathway
  • NEDD4 and ARRB1 as key regulators of SLC9A1 ubiquitylation, endocytosis, and function
  • SHH inducing ARRB1 accumulation and localization to the nucleus, where it participates in enhancing expression of CDKN1B, whose accumulation eventually drives granule neuron precursors (CGNPs) cell cycle exit
  • plays a central role in coupling MIF endocytosis to sustained ERK activation
  • represses adipogenesis and inflammatory responses through its interaction with peroxisome proliferator-activated receptor-gamma (PPARG)
  • upon catecholamine stimulation, ARRB1 promotes the interaction of MDM2 and TP53 by acting as an E3 ligase adaptor that facilitates ubiquitination of p53
  • role for nuclear-localized ARRB1 in the regulation of NFKB activation
  • dispensable for STAT1 dephosphorylation and the termination of IFNG signaling
  • engagement of ACKR2 by its ligands activates a ARRB1-dependent, G protein-independent signaling pathway that results in the phosphorylation of the actin-binding protein cofilin through the RAC1-PAK1-LIMK1 cascade
  • cell & other
    REGULATION
    activated by AVPR2, that functionally and conformationally activate ARRB1
    Other phosphorylation by GRK5 that regulates G protein-independent signalling
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS