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FLASH GENE
Symbol ARPC1B contributors: - updated : 12-04-2007
HGNC name actin related protein 2/3 complex, subunit 1B, 41kDa
HGNC id 704
Location 7q22.1      Physical location : 98.972.328 - 98.992.402
Synonym symbol(s) ARC41, p40-ARC, p41-ARC
DNA
TYPE functioning gene
STRUCTURE 20.00 kb     10 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status confirmed
Physical map
NPTX2 7q21.3-q22.1 neuronal pentraxin II DKFZp761L1417 7q22.1 hypothetical protein DKFZp761L1417 TRRAP 7q21.3-q22.1 transformation/transcription domain-associated protein SMURF1 7q21.1-q31.1 transformation/transcription domain-associated protein LOC389539 7 similar to importin alpha 1b ARPC1A 7q22.1-q31.33 actin related protein 2/3 complex, subunit 1A, 41kDa ARPC1B 7q22.1-q31.33 actin related protein 2/3 complex, subunit 1B, 41kDa PDAP1 7q11.21 PDGFA associated protein 1 G10 7q11.21 PDGFA associated protein 1 CPSF4 7q22.1 cleavage and polyadenylation specific factor 4, 30kDa KIAA0632 7q22.1 cleavage and polyadenylation specific factor 4, 30kDa ATP5J2 7q21.3-q22 ATP synthase, H+ transporting, mitochondrial F0 complex, subunit f, isoform 2 LOC285989 7q22.1 hypothetical protein LOC285989 ZNF394 7q22.1 zinc finger protein 394 ZFP95 7q22 zinc finger protein 95 homolog (mouse) DKFZp727G131 7q22.1 hypothetical protein DKFZp727G131 VIK 7q22.1 vav-1 interacting Kruppel-like protein ZNF498 7q22.1 zinc finger protein 498 CYP3A5 7q21.3-q22.1 cytochrome P450, family 3, subfamily A, polypeptide 5 CYP3A5P1 7q21.3-q22.1 cytochrome P450, family 3, subfamily A, polypeptide 5 pseudogene 1 CYP3A7 7q21.3-q22.1 cytochrome P450, family 3, subfamily A, polypeptide 7 CYP3A5P2 7q21.3-q22.1 cytochrome P450, family 3, subfamily A, polypeptide 5 pseudogene 2 CYP3A4 7q21.3-q22.1 cytochrome P450, family 3, subfamily A, polypeptide 4 CYP3A43 7q21.1 cytochrome P450, family 3, subfamily A, polypeptide 43 TRIM4 7q22-q31.1 tripartite motif-containing 4
RNA
TRANSCRIPTS type messenger
EXPRESSION
Type ubiquitous
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveintestinelarge intestinecolon moderately
 salivary gland   highly
 stomach   moderately
Endocrinepancreas   moderately
Lymphoid/Immunetonsils   highly
Nervousnervecranial nerve  moderately
Reproductivefemale systemplacenta  moderately
 female systembreastmammary gland moderately
 female systemuteruscervix moderately
Respiratorylung   moderately
Skin/Tegumentskin   moderately
Visualeye   moderately
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Blood / hematopoieticbone marrow  moderately
Connective   moderately
Connectiveadipose  moderately
cells
SystemCellPubmedSpeciesStageRna symbol
 digestive
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period embryo
Text embryonic tissue at a lowly level
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • six WD repeat
  • mono polymer homomer , heteromer , complex
    HOMOLOGY
    interspecies homolog to yeast S.pombe Sop2-like
    homolog to chimpanzee ARPC1B (99,45 pc)
    homolog to rattus Arpc1b (96,77 pc)
    homolog to murine Arpc1b (97,04 pc)
    homolog to chicken ARPC1B (91,16 pc)
    Homologene
    FAMILY
  • SOP2 family
  • WD repeat ARPC1 family
  • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytoskeleton
    text
  • localized to the lamellipoda of stationary and locomoting
  • basic FUNCTION
  • structural constituent of cytoskeleton
  • involved in the actin polymerization cell control
  • involved in gastric cancer development progression
  • used as a prediction marker gene for sensitivity of Choroidal Malignant Melanomas (CMM) to radiotherapy
  • CELLULAR PROCESS cell life, proliferation/growth
    cell organization/biogenesis
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • subunit 1B constituent of actin related protein 2/3 complex
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • actin
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS