Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol ARNTL2 contributors: mct - updated : 17-09-2011
HGNC name aryl hydrocarbon receptor nuclear translocator-like 2
HGNC id 18984
Location 12p11.23      Physical location : 27.485.987 - 27.573.466
Synonym name
  • transcription factor BMAL2, member of PAS superfamily 9
  • ARNT-like protein 2, brain and muscle
  • cycle like factor
  • class E basic helix-loop-helix protein 6
  • member of PAS protein 9
  • CYCLE-like factor
  • Basic-helix-loop-helix-PAS protein MOP9
  • Synonym symbol(s) BMAL2, MOP9, CLIF, PASD9, bHLHe6, MGC149671, MGC149672
    DNA
    TYPE functioning gene
    STRUCTURE 87.48 kb     17 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Physical map
    LOC121153 12p12.1 similar to Brain protein I3 (pRGR2) LOC387847 12 LOC387847 LRMP 12p12.1 lymphoid-restricted membrane protein LAS1 LOC144363 12p12.1 hypothetical protein LOC144363 KRAS2 12p12.1 v-Ki-ras2 Kirsten rat sarcoma 2 viral oncogene homolog FLJ36004 12p12.1 hypothetical protein FLJ36004 LOC283347 12p12.1 similar to thymine-DNA glycosylase C12orf2 12p12.3 chromosome 12 open reading frame 2 BHLHB3 12p12.1-p11.23 basic helix-loop-helix domain containing, class B, 3 LOC387848 12 LOC387848 SSPN 12p11.2 sarcospan (Kras oncogene-associated gene) ITPR2 12p11 inositol 1,4,5-triphosphate receptor, type 2 LOC341370 12p12.1 similar to Dag1-prov protein FLJ10637 12p12.1 hypothetical protein FLJ10637 DKFZP564O1863 TM7SF3 12q11.2-q12 transmembrane 7 superfamily member 3 SURB7 12p12.3 SRB7 suppressor of RNA polymerase B homolog (yeast) LOC341371 12p12.1 hypothetical LOC341371 STK38L 12p12.3-p11.22 serine/threonine kinase 38 like ARNTL2 12p11.23-p11.22 aryl hydrocarbon receptor nuclear translocator-like 2 LOC341346 12p12.1 similar to hypothetical protein PPFIBP1 12q14.3 PTPRF interacting protein, binding protein 1 (liprin beta 1) LOC387849 12 similar to RIKEN cDNA 2210417D09 MRPS35 12p11 mitochondrial ribosomal protein S35 KIAA1340 12p12.1 KIAA1340 protein PTHLH 12p11.2 parathyroid hormone-like hormone FLJ11088 12p11.23 GGA binding partner FLJ10462 12p11.23 hypothetical protein FLJ10462 PTX1 12p11.23 PTX1 protein OVCH1 12p11.23 ovochymase 1 LOC387618 12 hypothetical gene supported by AK125140; NM_194311 ARG99 12p11.23 ARG99 protein
    RNA
    TRANSCRIPTS type messenger
    text three novel transcripts differing in their N terminus (PMID: 12738229)
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    - splicing 1970 62.92 572 brain 2003 12738229
    also called MOP9 short
    - splicing 7267 64.68 588 fetal brain, adult liver 2003 12738229
    also called ARNTL2d or BMAL2d
    - splicing 6792 66.22 602 umbilical vein, endothelial cells 2003 12738229
  • also called CLIF
  • - splicing 2008 64.35 585 - 2003 12738229
    also called MOP9 long
    17 splicing 1930 70.89 636 - 2003 12738229
    also called ARNTL2a or BMAL2a
    - splicing 7369 68.42 622 - 2003 12738229
  • also called ARNTL2b or BMAL2b
  • - splicing 7300 65.89 599 - 2003 12738229
  • also called ARNTL2c or BMAL2c
  • - - 7191 - 540 - -
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveesophagus   highly
     intestinelarge intestinecolon lowly
     liver   lowly
     mouth   moderately
     pharynx   moderately
    Endocrinethyroid   highly
    Nervousbraindiencephalonhypothalamus lowly
     braindiencephalonthalamus lowly
    Reproductivefemale systemuterus  moderately
     female systemplacenta  moderately
    Respiratoryrespiratory tracttrachea  highly
     respiratory tractlarynx  highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / hematopoieticbone marrow  moderately
    Epithelialbarrier/lining   
    Muscularstriatumskeletal lowly
    Nervousperipherous   
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Cardiovascularendothelial cell
    Nervousneuron
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period fetal
    Text brain (thalamus, hypothalamus)
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a basic helix-loop-helix (HLH)
  • two PAS (PER - ARNT - SIM) domains at the N terminal region
  • a variable C terminus
  • mono polymer heteromer , dimer
    HOMOLOGY
    interspecies homolog to murine Arntl2 (73.08 pc)
    homolog to Drosophila circadian factor CYCLE (50.00 pc)
    intraspecies paralog to CLOCK
    homolog to ARNT
    Homologene
    FAMILY
  • PAS superfamily
  • CATEGORY transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,chromatin/chromosome
    basic FUNCTION
  • regulating circadian oscillation of SERPINE1
  • involved in the control of type 1 diabetes
  • potentially playing an active role in the circadian transcription
  • has a minimal role in the clock system
  • ARNTL2, ARNTL form a circadian paralog pair that is functionally redundant
  • CELLULAR PROCESS nucleotide, transcription
    PHYSIOLOGICAL PROCESS circadian
    PATHWAY
    metabolism
    signaling signal transduction
    a component colocalizing and heterodimerizing with CLOCK, HF1A, NPAS2 (MOP4)
    INTERACTION
    DNA binding to an E-box element (5'-GTGCAC-3')
    RNA
    small molecule
    protein
  • CLOCK and HIF1A (heterodimeric partner of circadian and hypoxia factors)
  • interaction with ID2 (could potentially regulate aspects of both clock input and output through a time-of-day specific interaction with CLOCK and ARNTL1)
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    in hepatocellular carcinoma
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS